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Tclin
NDUFB8
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

Protein Classes
Protein Summary
Description
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299166
  • ENSP00000299166
  • ENSG00000166136
  • ENST00000370320
  • ENSP00000359344
  • ENST00000370322
  • ENSP00000359346

Symbol
  • ASHI
  • CI-ASHI
  • MC1DN32
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
0.94
transcription factor perturbation
0.91
kinase perturbation
0.88
cell type or tissue
0.74


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.69   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.69   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
chemical structure image
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit B8
VGNC:12384
744716
Mouse
MGI:1914514
67264
Rat
RGD:1309129
293991
Dog
NADH:ubiquinone oxidoreductase subunit B8
VGNC:53001
477798
Cow
NADH:ubiquinone oxidoreductase subunit B8
282517
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit B8
Mouse
Rat
Dog
NADH:ubiquinone oxidoreductase subunit B8
Cow
NADH:ubiquinone oxidoreductase subunit B8
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95169-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Mitochondrial protein import
Reactome
Protein localization
Reactome
Respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Mitochondrial protein import
Protein localization
Respiratory electron transport
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (254)
1 – 10 of 254
GCG
Tchem
Novelty: 0.00004879
p_int: 0.999999256
p_ni: 7.23e-7
p_wrong: 2.1e-8
Data Source: BioPlex
NDUFB11
Tclin
Family: Enzyme
Novelty: 0.0401232
p_int: 0.999997945
p_ni: 0.000002055
Score: 0.998
Data Source: BioPlex,STRINGDB
NDUFA7
Tclin
Family: Enzyme
Novelty: 0.16417588
p_int: 0.999997316
p_ni: 0.000002684
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFS3
Tclin
Family: Enzyme
Novelty: 0.01968313
p_int: 0.999992161
p_ni: 0.000007824
p_wrong: 1.5e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFS6
Tclin
Family: Enzyme
Novelty: 0.07910252
p_int: 0.999929811
p_ni: 0.000070189
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFA8
Tclin
Family: Enzyme
Novelty: 0.05772867
p_int: 0.999899915
p_ni: 0.000100084
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
CUX1
Tbio
Novelty: 0.00415896
p_int: 0.99986415
p_ni: 0.000135851
Data Source: BioPlex
YIPF3
Tbio
Novelty: 0.12021667
p_int: 0.999472352
p_ni: 0.000269629
p_wrong: 0.000258019
Data Source: BioPlex
NDUFS7
Tclin
Family: Enzyme
Novelty: 0.01562198
p_int: 0.998880404
p_ni: 0.00111704
p_wrong: 0.000002556
Score: 0.999
Data Source: BioPlex,STRINGDB
PRRT2
Tbio
Novelty: 0.00442931
p_int: 0.998355862
p_ni: 0.001644061
p_wrong: 7.7e-8
Score: 0.169
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  35.69

PubMed score by year
PubTator Score  75.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer