You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ELP1
Elongator complex protein 1

Protein Summary
Description
May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK). Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration. Involved in neurogenesis (By similarity). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). The protein encoded by this gene is a scaffold protein and a regulator for three different kinases involved in proinflammatory signaling. The encoded protein can bind NF-kappa-B-inducing kinase and I-kappa-B kinases through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with fam ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374647
  • ENSP00000363779
  • ENSG00000070061

Symbol
  • IKAP
  • IKBKAP
  • FD
  • DYS
  • IKAP
  • IKI3
  • TOT1
  • IKBKAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 313.22   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 313.22   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glucose measurement
2
2
2
78.2
self reported educational attainment
1
1
1
70.2
mathematical ability
2
2
2
68.4
body height
1
1
1
57.8
fasting blood glucose measurement
1
1
1
56.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glucose measurement
2
78.2
self reported educational attainment
1
70.2
mathematical ability
2
68.4
body height
1
57.8
fasting blood glucose measurement
1
56.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
elongator complex protein 1
VGNC:48979
473014
Macaque
elongator complex protein 1
713524
Mouse
MGI:1914544
230233
Rat
RGD:620072
140934
Dog
elongator complex protein 1
VGNC:40326
612455
Species
Name
OMA
EggNOG
Inparanoid
Chimp
elongator complex protein 1
Macaque
elongator complex protein 1
Mouse
Rat
Dog
elongator complex protein 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95163-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
PDGF signaling pathway
PathwayCommons: netpath
TNFalpha
PathwayCommons: netpath
IL1
Name
Explore in Pharos
Explore in Source
PDGF signaling pathway
TNFalpha
IL1
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (117)
1 – 10 of 117
ELP3
Tbio
Family:  Epigenetic
Novelty:  0.0166061
p_int:  0.999949746
p_ni:  0.000050255
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
MPG
Tchem
Family:  Enzyme
Novelty:  0.00373538
p_int:  0.962282645
p_ni:  0.037717355
Score:  0.685
Data Source:  BioPlex,STRINGDB
ELP2
Tbio
Novelty:  0.03034629
Score:  0.999
Data Source:  Reactome,STRINGDB
ELP4
Tbio
Novelty:  0.03734233
Score:  0.999
Data Source:  Reactome,STRINGDB
ELP6
Tbio
Novelty:  0.01229878
Score:  0.982
Data Source:  Reactome,STRINGDB
ELP5
Tbio
Novelty:  0.07212185
Score:  0.935
Data Source:  Reactome,STRINGDB
KTI12
Tdark
Novelty:  0.08954294
Score:  0.885
Data Source:  STRINGDB
NOC3L
Tbio
Novelty:  0.05635731
Score:  0.85
Data Source:  STRINGDB
DDX27
Tbio
Family:  Enzyme
Novelty:  0.20604441
Score:  0.819
Data Source:  STRINGDB
DPH3
Tdark
Novelty:  0.05288317
Score:  0.814
Data Source:  STRINGDB
Publication Statistics
PubMed Score  313.22

PubMed score by year
PubTator Score  105.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: