You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
AKR7A3
Aflatoxin B1 aldehyde reductase member 3

Protein Summary
Description
Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. Aldo-keto reductases, such as AKR7A3, are involved in the detoxification of aldehydes and ketones.[supplied by OMIM, Apr 2004]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361640
  • ENSP00000355377
  • ENSG00000162482

Symbol
  • AFAR2
  • AFAR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.79
disease
0.76
disease perturbation
0.74
chemical
0.66
virus perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.43   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.43   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (29)
AKR7L
Tdark
Family:  Enzyme
p_int:  1
Data Source:  BioPlex
AKR7A2
Tbio
Family:  Enzyme
Novelty:  0.00917827
p_int:  0.999994409
p_ni:  0.000005591
Score:  0.981
Data Source:  BioPlex,STRINGDB
COMMD9
Tdark
Novelty:  0.77223999
p_int:  0.999199543
p_ni:  0.00079272
p_wrong:  0.000007737
Score:  0.219
Data Source:  BioPlex,STRINGDB
DDRGK1
Tbio
Novelty:  0.10774064
p_int:  0.998185228
p_ni:  0.001814772
Score:  0.178
Data Source:  BioPlex,STRINGDB
GNB2
Tbio
Novelty:  0.08682553
p_int:  0.908682162
p_ni:  0.091317836
p_wrong:  2e-9
Score:  0.169
Data Source:  BioPlex,STRINGDB
FNDC11
Tdark
Novelty:  20.00979352
p_int:  0.859457742
p_ni:  0.140542258
Score:  0.309
Data Source:  BioPlex,STRINGDB
MSC
Tbio
Family:  TF
Novelty:  0.00727355
Score:  0.743
Data Source:  STRINGDB
AKR1A1
Tchem
Family:  Enzyme
Novelty:  0.0054436
Score:  0.698
Data Source:  STRINGDB
VPS13D
Tdark
Novelty:  0.12578583
Score:  0.633
Data Source:  STRINGDB
MRTO4
Tbio
Novelty:  0.06676322
Score:  0.631
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (413)
Aflatoxin activation and detoxification (R-HSA-5423646)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aflatoxin activation and detoxification
Reactome
Biological oxidations
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Aflatoxin activation and detoxification
Biological oxidations
Metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
1
1
1
77.7
viral load
1
1
1
68.6
BMI-adjusted hip circumference
1
1
1
45.7
platelet count
1
1
1
42.3
Thyroid preparation use measurement
1
1
1
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
1
77.7
viral load
1
68.6
BMI-adjusted hip circumference
1
45.7
platelet count
1
42.3
Thyroid preparation use measurement
1
26.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Pig
aldo-keto reductase family 7 member A2
100511331
Chicken
aldo-keto reductase family 7 member A2
CGNC:51005
419471
Anole lizard
aflatoxin B1 aldehyde reductase member 2
100558513
Xenopus
aldo-keto reductase family 7, member A2
XB-GENE-996153
447982
Zebrafish
ZDB-GENE-040718-62
436642
Species
Name
OMA
EggNOG
Inparanoid
Pig
aldo-keto reductase family 7 member A2
Chicken
aldo-keto reductase family 7 member A2
Anole lizard
aflatoxin B1 aldehyde reductase member 2
Xenopus
aldo-keto reductase family 7, member A2
Zebrafish
Publication Statistics
PubMed Score 9.43
PubMed score by year
PubTator Score 3.03
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title