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Tbio
AKR7A3
Aflatoxin B1 aldehyde reductase member 3

Protein Classes
Protein Summary
Description
Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. Aldo-keto reductases, such as AKR7A3, are involved in the detoxification of aldehydes and ketones.[supplied by OMIM, Apr 2004]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361640
  • ENSP00000355377
  • ENSG00000162482

Symbol
  • AFAR2
  • AFAR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.79
disease
0.76
disease perturbation
0.74
chemical
0.66
virus perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.74   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.74   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (413)
Aflatoxin activation and detoxification (R-HSA-5423646)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aflatoxin activation and detoxification
Reactome
Biological oxidations
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Aflatoxin activation and detoxification
Biological oxidations
Metabolism
Protein-Protein Interactions (29)
1 – 10 of 29
AKR7L
Tdark
Family: Enzyme
p_int: 1
Data Source: BioPlex
AKR7A2
Tbio
Family: Enzyme
Novelty: 0.00220647
p_int: 0.999994409
p_ni: 0.000005591
Score: 0.981
Data Source: BioPlex,STRINGDB
COMMD9
Tdark
Novelty: 1.08065314
p_int: 0.999199543
p_ni: 0.00079272
p_wrong: 0.000007737
Score: 0.219
Data Source: BioPlex,STRINGDB
DDRGK1
Tbio
Novelty: 0.10926955
p_int: 0.998185228
p_ni: 0.001814772
Score: 0.178
Data Source: BioPlex,STRINGDB
GNB2
Tbio
Novelty: 0.20536996
p_int: 0.908682162
p_ni: 0.091317836
p_wrong: 2e-9
Score: 0.169
Data Source: BioPlex,STRINGDB
FNDC11
Tdark
p_int: 0.859457742
p_ni: 0.140542258
Score: 0.309
Data Source: BioPlex,STRINGDB
MSC
Tbio
Family: TF
Novelty: 0.00544677
Score: 0.743
Data Source: STRINGDB
AKR1A1
Tchem
Family: Enzyme
Novelty: 0.00656392
Score: 0.698
Data Source: STRINGDB
VPS13D
Tdark
Novelty: 0.22775975
Score: 0.633
Data Source: STRINGDB
MRTO4
Tbio
Novelty: 0.09036145
Score: 0.631
Data Source: STRINGDB
Publication Statistics
PubMed Score  18.74

PubMed score by year
PubTator Score  3.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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