TNFSF15
Tumor necrosis factor ligand superfamily member 15
Protein Classes
Protein Summary
Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
- ENST00000374045
- ENSP00000363157
- ENSG00000181634
- TL1
- VEGI
- TL1
- TL1A
- VEGI
- TNLG1B
- VEGI192A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.88 | ||
phenotype | 0.85 | ||
biological process | 0.75 | ||
trait | 0.75 | ||
biological term | 0.72 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 489.75 (req: < 5)
Gene RIFs: 114 (req: <= 3)
Antibodies: 681 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 489.75 (req: >= 5)
Gene RIFs: 114 (req: > 3)
Antibodies: 681 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
7 | 7 | 0 | 1.2 | 98.5 | |||||
2 | 2 | 0 | 1.4 | 98.2 | |||||
3 | 3 | 0 | 1.1 | 96.1 | |||||
2 | 1 | 0 | 1.6 | 87.4 | |||||
3 | 2 | 0 | 1.1 | 85.5 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.2 | 98.5 | |||||
0 | 1.4 | 98.2 | |||||
0 | 1.1 | 96.1 | |||||
0 | 1.6 | 87.4 | |||||
0 | 1.1 | 85.5 | |||||
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | TNF superfamily member 15 | VGNC:13980 | 473468 | |||||
Macaque | TNF superfamily member 15 | 703189 | ||||||
Mouse | MGI:2180140 | 326623 | ||||||
Rat | RGD:628735 | 252878 | ||||||
Dog | TNF superfamily member 15 | VGNC:47671 | 481688 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | TNF superfamily member 15 | |||||
Macaque | TNF superfamily member 15 | |||||
Mouse | ||||||
Rat | ||||||
Dog | TNF superfamily member 15 | |||||
Protein Structure (7 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 7
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (28)
Reactome (4)
KEGG (1)
WikiPathways (23)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | TNFR2 non-canonical NF-kB pathway | ||||
Reactome | TNFs bind their physiological receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Immune System | ||||
TNFR2 non-canonical NF-kB pathway | ||||
TNFs bind their physiological receptors | ||||
Gene Ontology Terms (14)
Functions (3)
Components (4)
Processes (7)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (56)
1 – 10 of 56
TNFRSF25
Novelty: 0.0005039
Score: 0.991
Data Source: Reactome,STRINGDB
TNFRSF6B
Novelty: 0.00711845
Score: 0.976
Data Source: Reactome,STRINGDB
TNFSF4
Novelty: 0.00308925
Score: 0.696
Data Source: STRINGDB
IL13
Novelty: 0.00021435
Score: 0.673
Data Source: STRINGDB
IL23R
Novelty: 0.00434717
Score: 0.668
Data Source: STRINGDB
CCDC122
Novelty: 0.4560176
Score: 0.66
Data Source: STRINGDB
LITAF
Family: TF
Novelty: 0.0097203
Score: 0.654
Data Source: STRINGDB
NOD2
Novelty: 0.00059089
Score: 0.644
Data Source: STRINGDB
TNFRSF1A
Novelty: 0.00037847
Score: 0.635
Data Source: STRINGDB
TNFSF18
Novelty: 0.01423949
Score: 0.631
Data Source: STRINGDB
Publication Statistics
PubMed Score 489.75
PubMed score by year
PubTator Score 181.88
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword
GWAS Trait