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Tbio
TNFSF15
Tumor necrosis factor ligand superfamily member 15

Protein Summary
Description
Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374045
  • ENSP00000363157
  • ENSG00000181634

Symbol
  • TL1
  • VEGI
  • TL1
  • TL1A
  • VEGI
  • TNLG1B
  • VEGI192A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
phenotype
0.85
biological process
0.75
trait
0.75
biological term
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 489.75   (req: < 5)
Gene RIFs: 114   (req: <= 3)
Antibodies: 681   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 489.75   (req: >= 5)
Gene RIFs: 114   (req: > 3)
Antibodies: 681   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
7
0
1.2
98.5
2
2
0
1.4
98.2
3
3
0
1.1
96.1
2
1
0
1.6
87.4
3
2
0
1.1
85.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
98.5
0
1.4
98.2
0
1.1
96.1
0
1.6
87.4
0
1.1
85.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF superfamily member 15
VGNC:13980
473468
Macaque
TNF superfamily member 15
703189
Mouse
MGI:2180140
326623
Rat
RGD:628735
252878
Dog
TNF superfamily member 15
VGNC:47671
481688
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF superfamily member 15
Macaque
TNF superfamily member 15
Mouse
Rat
Dog
TNF superfamily member 15
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95150-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (28)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
TNFR2 non-canonical NF-kB pathway
Reactome
TNFs bind their physiological receptors
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
Protein-Protein Interactions (56)
1 – 10 of 56
TNFRSF25
Tbio
Novelty: 0.0005039
Score: 0.991
Data Source: Reactome,STRINGDB
TNFRSF6B
Tbio
Novelty: 0.00711845
Score: 0.976
Data Source: Reactome,STRINGDB
TNFSF4
Tbio
Novelty: 0.00308925
Score: 0.696
Data Source: STRINGDB
IL13
Tbio
Novelty: 0.00021435
Score: 0.673
Data Source: STRINGDB
IL23R
Tbio
Novelty: 0.00434717
Score: 0.668
Data Source: STRINGDB
CCDC122
Tdark
Novelty: 0.4560176
Score: 0.66
Data Source: STRINGDB
LITAF
Tbio
Family: TF
Novelty: 0.0097203
Score: 0.654
Data Source: STRINGDB
NOD2
Tclin
Novelty: 0.00059089
Score: 0.644
Data Source: STRINGDB
TNFRSF1A
Tchem
Novelty: 0.00037847
Score: 0.635
Data Source: STRINGDB
TNFSF18
Tbio
Novelty: 0.01423949
Score: 0.631
Data Source: STRINGDB
Publication Statistics
PubMed Score  489.75

PubMed score by year
PubTator Score  181.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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