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Tbio
SNUPN
Snurportin-1

Protein Summary
Description
Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308588
  • ENSP00000309831
  • ENSG00000169371
  • ENST00000564644
  • ENSP00000454852
  • ENST00000564675
  • ENSP00000458053
  • ENST00000567134
  • ENSP00000456224

Symbol
  • RNUT1
  • SPN1
  • KPNBL
  • RNUT1
  • Snurportin1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
transcription factor binding site profile
0.79
interacting protein
0.77
tissue sample
0.7
histone modification site profile
0.68


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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.22   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.22   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1913319
66069
Rat
RGD:1303191
316108
Dog
snurportin 1
VGNC:46618
487655
Horse
snurportin 1
VGNC:51420
100051100
Cow
snurportin 1
VGNC:35088
515588
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
snurportin 1
Horse
snurportin 1
Cow
snurportin 1
Protein Structure (11 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95149-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Metabolism of non-coding RNA
Reactome
snRNP Assembly
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Metabolism of non-coding RNA
snRNP Assembly
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (101)
1 – 10 of 101
SNRPB2
Tbio
Novelty: 0.17219587
p_int: 0.999972153
p_ni: 0.000027287
p_wrong: 5.6e-7
Score: 0.196
Data Source: BioPlex,STRINGDB
SNRPA1
Tbio
Novelty: 0.01232044
p_int: 0.999909791
p_ni: 0.000090209
Score: 0.744
Data Source: BioPlex,STRINGDB
PDP1
Tbio
Family: Enzyme
Novelty: 0.00442352
p_int: 0.999563548
p_ni: 0.000436452
Score: 0.29
Data Source: BioPlex,STRINGDB
SNRPE
Tbio
Novelty: 0.02033423
p_int: 0.998418216
p_ni: 0.001581784
Score: 0.967
Data Source: BioPlex,STRINGDB
SNRPN
Tbio
Novelty: 0.002157
p_int: 0.989614676
p_ni: 0.01030817
p_wrong: 0.000077154
Score: 0.626
Data Source: BioPlex,STRINGDB
TOE1
Tbio
Novelty: 0.03660884
p_int: 0.97555527
p_ni: 0.02444473
Score: 0.858
Data Source: BioPlex,STRINGDB
KPNB1
Tbio
Novelty: 0.01469696
Score: 0.993
Data Source: STRINGDB
XPO1
Tclin
Novelty: 0.00078187
Score: 0.992
Data Source: STRINGDB
SNRPD1
Tbio
Novelty: 0.0136355
Score: 0.991
Data Source: STRINGDB
DDX20
Tbio
Family: Enzyme
Novelty: 0.01854078
Score: 0.966
Data Source: STRINGDB
Publication Statistics
PubMed Score  22.22

PubMed score by year
PubTator Score  21.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer