You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
NDUFB6
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6

Protein Summary
Description
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350021
  • ENSP00000297983
  • ENSG00000165264
  • ENST00000379847
  • ENSP00000369176

Symbol
  • CI
  • B17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
virus perturbation
0.94
disease perturbation
0.83
cell type or tissue
0.82
transcription factor binding site profile
0.77


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.79   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.79   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
chemical structure image
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit B6
VGNC:4800
100611615
Macaque
NADH:ubiquinone oxidoreductase subunit B6
704867
Mouse
MGI:2684983
230075
Rat
RGD:1311354
297990
Dog
NADH:ubiquinone oxidoreductase subunit B6
VGNC:43704
100687033
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit B6
Macaque
NADH:ubiquinone oxidoreductase subunit B6
Mouse
Rat
Dog
NADH:ubiquinone oxidoreductase subunit B6
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95139-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (175)
1 – 10 of 175
NDUFV3
Tclin
Family: Enzyme
Novelty: 0.15352039
p_int: 0.999999979
p_ni: 1.6e-8
p_wrong: 5e-9
Score: 0.993
Data Source: BioPlex,STRINGDB
NDUFB11
Tclin
Family: Enzyme
Novelty: 0.0401232
p_int: 0.999999699
p_ni: 3.01e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFA7
Tclin
Family: Enzyme
Novelty: 0.16417588
p_int: 0.999998725
p_ni: 0.000001275
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB5
Tclin
Family: Enzyme
Novelty: 0.0257403
p_int: 0.999976463
p_ni: 0.000023467
p_wrong: 7e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFS3
Tclin
Family: Enzyme
Novelty: 0.01968313
p_int: 0.999974034
p_ni: 0.000025956
p_wrong: 9e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFA9
Tclin
Family: Enzyme
Novelty: 0.00637307
p_int: 0.999973211
p_ni: 0.000026787
p_wrong: 3e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFS6
Tclin
Family: Enzyme
Novelty: 0.07910252
p_int: 0.999970698
p_ni: 0.000029295
p_wrong: 7e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB3
Tclin
Family: Enzyme
Novelty: 0.13020753
p_int: 0.999870246
p_ni: 0.000126814
p_wrong: 0.00000294
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFA8
Tclin
Family: Enzyme
Novelty: 0.05772867
p_int: 0.999514442
p_ni: 0.000482862
p_wrong: 0.000002696
Score: 0.999
Data Source: BioPlex,STRINGDB
YIPF3
Tbio
Novelty: 0.12021667
p_int: 0.999475021
p_ni: 0.000522116
p_wrong: 0.000002863
Data Source: BioPlex
Publication Statistics
PubMed Score  10.79

PubMed score by year
PubTator Score  132.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer