Tchem S1PR2 Sphingosine 1-phosphate receptor 2

Protein Summary

Description

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10617617). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (PubMed:10617617). When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis (PubMed:10617617). Receptor for the chemokine-like protein FAM19A5 (PubMed:29453251). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity). This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in this gene have been associated with congenital profound deafness. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• O95136
• Q86UN8
• S1P receptor 2

Gene Name

• S1PR2

Ensembl ID

• ENST00000590320
• ENSP00000466933
• ENSG00000267534
• ENST00000646641
• ENSP00000496438

Symbol

• EDG5
• EDG5
• H218
• LPB2
• S1P2
• AGR16
• EDG-5
• DFNB68
• Gpcr13

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.79
transcription factor	0.71
microRNA	0.7
biological process	0.64
molecular function	0.63

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Sphingosine 1-phosphate Receptor 2

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Sphingosine 1-phosphate Receptor 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 374.9   (req: < 5)

Gene RIFs: 73   (req: <= 3)

Antibodies: 290   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 374.9   (req: >= 5)

Gene RIFs: 73   (req: > 3)

Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 128

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1