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Tbio
SCAF4
Splicing factor, arginine/serine-rich 15

Protein Summary
Description
May act to physically and functionally link transcription and pre-mRNA processing. This gene likely encodes a member of the arginine/serine-rich splicing factor family. A similar protein in Rat appears to bind the large subunit of RNA polymerase II and provide a link between transcription and pre-mRNA splicing. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286835
  • ENSP00000286835
  • ENSG00000156304
  • ENST00000399804
  • ENSP00000382703
  • ENST00000434667
  • ENSP00000402377

Symbol
  • KIAA1172
  • SFRS15
  • SRA4
  • SFRS15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
0.93
virus perturbation
0.85
transcription factor binding site profile
0.81
histone modification site profile
0.74
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.39   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.39   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
2
3
86.1
sex hormone-binding globulin measurement
1
1
1
65.7
C-reactive protein measurement
1
1
1
65.2
self reported educational attainment
1
1
1
57.1
apolipoprotein B measurement
1
1
1
8.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
86.1
sex hormone-binding globulin measurement
1
65.7
C-reactive protein measurement
1
65.2
self reported educational attainment
1
57.1
apolipoprotein B measurement
1
8.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SR-related CTD associated factor 4
VGNC:8670
474092
Macaque
SR-related CTD associated factor 4
701931
Mouse
MGI:2146350
224432
Rat
RGD:727896
245924
Dog
SR-related CTD associated factor 4
VGNC:53039
100687160
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SR-related CTD associated factor 4
Macaque
SR-related CTD associated factor 4
Mouse
Rat
Dog
SR-related CTD associated factor 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95104-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (84)
1 – 10 of 84
CHCHD2
Tbio
Novelty: 0.01615338
p_int: 0.999820619
p_ni: 0.000179346
p_wrong: 3.5e-8
Data Source: BioPlex
PRM2
Tbio
Novelty: 0.0050028
p_int: 0.999806599
p_ni: 0.000193401
Data Source: BioPlex
JMJD6
Tbio
Family: Enzyme
Novelty: 0.00305479
p_int: 0.999595864
p_ni: 0.000404129
p_wrong: 7e-9
Data Source: BioPlex
QPRT
Tbio
Family: Enzyme
Novelty: 0.00781554
p_int: 0.984918662
p_ni: 0.014065343
p_wrong: 0.001015995
Score: 0.175
Data Source: BioPlex,STRINGDB
H1FNT
Tdark
Novelty: 0.05593238
p_int: 0.984321215
p_ni: 0.015460575
p_wrong: 0.000218209
Data Source: BioPlex
POLR2J
Tbio
Family: Enzyme
Novelty: 0.02344868
p_int: 0.963611038
p_ni: 0.036213056
p_wrong: 0.000175906
Data Source: BioPlex
LUC7L
Tbio
Novelty: 0.05748021
p_int: 0.956174044
p_ni: 0.043688726
p_wrong: 0.000137229
Score: 0.269
Data Source: BioPlex,STRINGDB
SLC13A2
Tbio
Family: Transporter
Novelty: 0.01020451
p_int: 0.823768614
p_ni: 0.002395622
p_wrong: 0.173835764
Score: 0.232
Data Source: BioPlex,STRINGDB
HLX
Tbio
Family: TF
Novelty: 0.00982861
p_int: 0.781182237
p_ni: 0.018660497
p_wrong: 0.200157266
Score: 0.187
Data Source: BioPlex,STRINGDB
VAPB
Tbio
Novelty: 0.00542377
Score: 0.829
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.39

PubMed score by year
PubTator Score  1.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer