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Tbio
PRSS23
Serine protease 23

Protein Summary
Description
This gene encodes a conserved member of the trypsin family of serine proteases. Mouse studies found a decrease of mRNA levels of this gene after ovulation was induced. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280258
  • ENSP00000280258
  • ENSG00000150687

Symbol
  • ZSIG13
  • SIG13
  • SPUVE
  • ZSIG13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
PubMedID
0.99
small molecule perturbation
0.73
kinase perturbation
0.71
disease perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.6   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.6   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
2
4
93.7
intraocular pressure measurement
3
4
5
81.5
blood urea nitrogen measurement
1
1
1
56.6
cup-to-disc ratio measurement
2
2
2
54.3
serum urea measurement
1
1
1
36.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
93.7
intraocular pressure measurement
5
81.5
blood urea nitrogen measurement
1
56.6
cup-to-disc ratio measurement
2
54.3
serum urea measurement
1
36.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
protease, serine 23
704537
Mouse
MGI:1923703
76453
Rat
RGD:1359545
308807
Dog
serine protease 23
VGNC:45065
485150
Horse
serine protease 23
VGNC:21914
100060937
Species
Name
OMA
EggNOG
Inparanoid
Macaque
protease, serine 23
Mouse
Rat
Dog
serine protease 23
Horse
serine protease 23
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95084-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (123)
1 – 10 of 123
CRP
Tbio
Novelty:  0.00001517
p_int:  0.999998772
p_ni:  0.000001217
p_wrong:  1e-8
Data Source:  BioPlex
KLRG2
Tdark
Novelty:  1.19446694
p_int:  0.999195735
p_ni:  0.000008784
p_wrong:  0.00079548
Data Source:  BioPlex
ACTB
Tbio
Novelty:  0.00006048
p_int:  0.950714248
p_ni:  0.049285752
Score:  0.278
Data Source:  BioPlex,STRINGDB
COL5A1
Tbio
Novelty:  0.00506815
p_int:  0.943247269
p_ni:  0.000159095
p_wrong:  0.056593635
Score:  0.322
Data Source:  BioPlex,STRINGDB
SCGB2A2
Tbio
Novelty:  0.01594053
p_int:  0.933426938
p_ni:  0.000074456
p_wrong:  0.066498606
Data Source:  BioPlex
UBR1
Tbio
Family:  Enzyme
Novelty:  0.00998888
p_int:  0.759485774
p_ni:  0.240514226
Score:  0.183
Data Source:  BioPlex,STRINGDB
SERPINC1
Tclin
Novelty:  0.00008721
Score:  0.939
Data Source:  STRINGDB
FN1
Tchem
Novelty:  0.00003647
Score:  0.931
Data Source:  STRINGDB
LTBP1
Tbio
Novelty:  0.00958396
Score:  0.919
Data Source:  STRINGDB
FAM20A
Tbio
Family:  Enzyme
Novelty:  0.03742119
Score:  0.917
Data Source:  STRINGDB
Publication Statistics
PubMed Score  10.60

PubMed score by year
PubTator Score  3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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