Tbio ALX3 Homeobox protein aristaless-like 3

Protein Summary

Description

Transcriptional regulator with a possible role in patterning of mesoderm during development. This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Preferential methylation of this gene's promoter is associated with advanced-stage neuroblastoma tumors. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O95076
• O95075
• Q5T8M4

Gene Name

• ALX3

Ensembl ID

• ENST00000369792
• ENSP00000358807
• ENSG00000156150
• ENST00000647563
• ENSP00000497310

Symbol

• FND
• FND1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.82
PubMedID	0.6
biological process	0.55
tissue	0.54
phenotype	0.5

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.63   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 110   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.63   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0