Tbio REC8 Meiotic recombination protein REC8 homolog

Protein Summary

Description

Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity). This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O95072
• A8K576
• D3DS62
• Q658V5
• Q6IA92
• Q8WUV8
• Q9BTF2
• Q9NVQ9

Gene Name

• REC8

Ensembl ID

• ENST00000611366
• ENSP00000482439
• ENSG00000100918
• ENST00000620473
• ENSP00000482546
• ENST00000642486
• ENSP00000493523
• ENSG00000285007
• ENST00000646765
• ENSP00000495458

Symbol

• REC8L1
• Rec8p
• REC8L1
• HR21spB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.65
transcription factor	0.64
cellular component	0.59
cell line	0.56
small molecule perturbation	0.55

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.47   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 207   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.47   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0