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Tclin
KCNK2
Potassium channel subfamily K member 2

Protein Summary
Description
Ion channel that contributes to passive transmembrane potassium transport (PubMed:23169818). Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner (PubMed:11319556). In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity). Isoform 4: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2. This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000391894
  • ENSP00000375764
  • ENSG00000082482
  • ENST00000391895
  • ENSP00000375765
  • ENST00000444842
  • ENSP00000394033
  • ENST00000467031
  • ENSP00000420203

Symbol
  • TREK
  • TREK1
  • TREK
  • TPKC1
  • TREK1
  • K2p2.1
  • TREK-1
  • hTREK-1c
  • hTREK-1e
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
disease perturbation
0.68
transcription factor
0.65
biological term
0.63
cellular component
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 362.17   (req: < 5)
Gene RIFs: 62   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 362.17   (req: >= 5)
Gene RIFs: 62   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 15
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 12
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (12)
chlorpromazine
Rendered image for chlorpromazine
halothane
Rendered image for halothane
isoflurane
Rendered image for isoflurane
desflurane
Rendered image for desflurane
sevoflurane
Rendered image for sevoflurane
fluphenazine
Rendered image for fluphenazine
haloperidol
Rendered image for haloperidol
carvedilol
Rendered image for carvedilol
pimozide
Rendered image for pimozide
propafenone
Rendered image for propafenone
Protein-Protein Interactions (57)
KCNK10
Tclin
Family:  IC
Novelty:  0.01313558
Score:  0.808
Data Source:  Reactome,STRINGDB
PRKACG
Tchem
Family:  Kinase
Novelty:  0.11080061
Score:  0.804
Data Source:  STRINGDB
PRKACA
Tchem
Family:  Kinase
Novelty:  0.03869658
Score:  0.804
Data Source:  STRINGDB
PRKACB
Tchem
Family:  Kinase
Novelty:  0.01962222
Score:  0.802
Data Source:  STRINGDB
NUDT6
Tbio
Novelty:  0.03648851
Score:  0.8
Data Source:  STRINGDB
TRPV1
Tclin
Family:  IC
Novelty:  0.00039493
Score:  0.673
Data Source:  STRINGDB
PIEZO1
Tchem
Family:  IC
Novelty:  0.00374633
Score:  0.655
Data Source:  STRINGDB
TRPA1
Tclin
Family:  IC
Novelty:  0.00093648
Score:  0.632
Data Source:  STRINGDB
COCH
Tbio
Novelty:  0.00819355
Score:  0.627
Data Source:  STRINGDB
BCCIP
Tbio
Novelty:  0.02710491
Score:  0.624
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Neuronal System
Reactome
Phase 4 - resting membrane potential
Reactome
Potassium Channels
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Neuronal System
Phase 4 - resting membrane potential
Potassium Channels
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
1
1
0
24.3
2.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
0
24.3
2.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium two pore domain channel subfamily K member 2
VGNC:8064
457734
Mouse
MGI:109366
16526
Rat
RGD:621448
170899
Dog
potassium two pore domain channel subfamily K member 2
VGNC:42274
490295
Horse
potassium two pore domain channel subfamily K member 2
VGNC:19297
100050114
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium two pore domain channel subfamily K member 2
Mouse
Rat
Dog
potassium two pore domain channel subfamily K member 2
Horse
potassium two pore domain channel subfamily K member 2
Publication Statistics
PubMed Score 362.17
PubMed score by year
PubTator Score 316.26
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Text