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Tbio
CCNB2
G2/mitotic-specific cyclin-B2

Protein Summary
Description
Essential for the control of the cell cycle at the G2/M (mitosis) transition. Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288207
  • ENSP00000288207
  • ENSG00000157456

Symbol
  • HsT17299
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.89
histone modification site profile
0.88
disease perturbation
0.83
gene perturbation
0.76
cellular component
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.08   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 547   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.08   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 547   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
3
4
57.1
serum metabolite measurement
1
1
2
56
pulse pressure measurement
1
1
1
46.9
platelet crit
1
1
1
33.1
phosphatidylethanolamine measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
57.1
serum metabolite measurement
2
56
pulse pressure measurement
1
46.9
platelet crit
1
33.1
phosphatidylethanolamine measurement
1
33.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin B2
VGNC:3571
453478
Macaque
cyclin B2
702184
Mouse
MGI:88311
12442
Dog
cyclin B2
478324
Horse
cyclin B2
VGNC:16206
100054413
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin B2
Macaque
cyclin B2
Mouse
Dog
cyclin B2
Horse
cyclin B2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95067-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (36)
Activation of NIMA Kinases NEK9, NEK6, NEK7 (R-HSA-2980767)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NIMA Kinases NEK9, NEK6, NEK7
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Reactome
Condensation of Prometaphase Chromosomes
Name
Explore in Pharos
Explore in Source
Activation of NIMA Kinases NEK9, NEK6, NEK7
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Condensation of Prometaphase Chromosomes
Gene Ontology Terms (24)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (448)
1 – 10 of 448
CKS1B
Tbio
Family:  Enzyme
Novelty:  0.00766779
p_int:  0.999999913
p_ni:  8.6e-8
Score:  0.994
Data Source:  BioPlex,STRINGDB
CRHBP
Tbio
Novelty:  0.00726484
p_int:  0.999998711
p_ni:  0.000001289
Score:  0.196
Data Source:  BioPlex,STRINGDB
CDK1
Tchem
Family:  Kinase
Novelty:  0.00040776
p_int:  0.999997675
p_ni:  0.000002325
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CKS2
Tbio
Family:  Enzyme
Novelty:  0.02482411
p_int:  0.999997122
p_ni:  0.000002878
Score:  0.997
Data Source:  BioPlex,STRINGDB
CDK2
Tchem
Family:  Kinase
Novelty:  0.00032118
p_int:  0.999961934
p_ni:  0.000038055
p_wrong:  1.1e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
WDFY1
Tbio
Novelty:  0.13382544
p_int:  0.99898247
p_ni:  0.001017037
p_wrong:  4.92e-7
Score:  0.334
Data Source:  BioPlex,STRINGDB
CDKN1A
Tchem
Family:  Enzyme
Novelty:  0.00033009
p_int:  0.998551117
p_ni:  0.001448883
Score:  0.886
Data Source:  BioPlex,STRINGDB
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.998422541
p_ni:  0.001577457
p_wrong:  2e-9
Score:  0.42
Data Source:  BioPlex,STRINGDB
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.997636264
p_ni:  0.002363711
p_wrong:  2.4e-8
Data Source:  BioPlex
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.997042178
p_ni:  0.002957808
p_wrong:  1.4e-8
Score:  0.154
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  138.08

PubMed score by year
PubTator Score  58.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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