Tbio RPP14 Ribonuclease P protein subunit p14

Protein Summary

Description

Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. This gene encodes a subunit of ribonuclease P and has 3' to 5' exoribonuclease activity. Transcripts for this gene are bicistronic and include a conserved downstream open reading frame for the hydroxyacyl-thioester dehydratase type 2 (HTD2) gene. [provided by RefSeq, May 2017]

Uniprot Accession IDs

• O95059
• Q53X97

Gene Name

• RPP14

Ensembl ID

• ENST00000295959
• ENSP00000295959
• ENSG00000163684
• ENST00000445193
• ENSP00000412894
• ENST00000466547
• ENSP00000419909

Symbol

• P14

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.9
transcription factor binding site profile	0.89
virus perturbation	0.83
kinase perturbation	0.81
cell type or tissue	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.04   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 71   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.04   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (129)

Explore Interacting Targets

1 – 10 of 129

• See Interactions on String-DB

RPP30

Tbio

Family:  Enzyme

Novelty:  0.01375777

p_int:  0.999999744

p_ni:  2.56e-7

Score:  0.998

Data Source:  BioPlex,STRINGDB

POP5

Tbio

Family:  Enzyme

Novelty:  0.02459167

p_int:  0.999998447

p_ni:  0.000001547

p_wrong:  6e-9

Score:  0.995

Data Source:  BioPlex,STRINGDB

C18orf21

Tdark

Novelty:  0.65363998

p_int:  0.999986681

p_ni:  0.000009127

p_wrong:  0.000004192

Score:  0.855

Data Source:  BioPlex,STRINGDB

RPP25L

Tdark

Family:  Enzyme

Novelty:  1.39761189

p_int:  0.999986601

p_ni:  0.000013396

p_wrong:  3e-9

Score:  0.699

Data Source:  BioPlex,STRINGDB

RPP21

Tbio

Family:  Enzyme

Novelty:  0.05805689

p_int:  0.999970786

p_ni:  0.000009761

p_wrong:  0.000019454

Score:  0.997

Data Source:  BioPlex,STRINGDB

POP4

Tbio

Family:  Enzyme

Novelty:  0.01072287

p_int:  0.999967821

p_ni:  0.000020738

p_wrong:  0.000011441

Score:  0.998

Data Source:  BioPlex,STRINGDB

RPP25

Tbio

Family:  Enzyme

Novelty:  0.07178063

p_int:  0.999875329

p_ni:  0.00012467

p_wrong:  1e-9

Score:  0.998

Data Source:  BioPlex,STRINGDB

NEPRO

Tbio

Novelty:  0.12980261

p_int:  0.999737001

p_ni:  0.000103964

p_wrong:  0.000159036

Score:  0.344

Data Source:  BioPlex,STRINGDB

RPP40

Tbio

Family:  Enzyme

Novelty:  0.05981624

Score:  0.997

Data Source:  STRINGDB

RPP38

Tbio

Family:  Enzyme

Novelty:  0.06387902

Score:  0.993

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (7)

Reactome (6)

KEGG (1)

Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

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5

1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Major pathway of rRNA processing in the nucleolus and cytosol	183 targets	R-HSA-6791226
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	rRNA processing	217 targets	R-HSA-72312
Reactome	rRNA processing in the nucleus and cytosol	193 targets	R-HSA-8868773
Reactome	tRNA processing	123 targets	R-HSA-72306

Name	Explore in Pharos	Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol	183 targets	R-HSA-6791226
Metabolism of RNA	686 targets	R-HSA-8953854
rRNA processing	217 targets	R-HSA-72312
rRNA processing in the nucleus and cytosol	193 targets	R-HSA-8868773
tRNA processing	123 targets	R-HSA-72306

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (6)

Functions (2)

Components (3)

Processes (1)

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1 – 2 of 2

GO Term	Evidence	Assigned by
RNA binding	Traceable Author Statement (TAS)	ProtInc
ribonuclease P activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

Disease Associations ()

No disease associations found

GWAS Traits (17)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 17

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hematocrit	EFO_0004348	2	2	2		88
low density lipoprotein cholesterol measurement	EFO_0004611	3	4	4		87.5
platelet count	EFO_0004309	2	2	2		82.5
aspartate aminotransferase measurement	EFO_0004736	1	1	0	13.3	82.5
red blood cell density measurement	EFO_0007978	1	1	1		77.3

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 17

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hematocrit	EFO_0004348	2		88
low density lipoprotein cholesterol measurement	EFO_0004611	4		87.5
platelet count	EFO_0004309	2		82.5
aspartate aminotransferase measurement	EFO_0004736	0	13.3	82.5
red blood cell density measurement	EFO_0007978	1		77.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Direct protein sequencing
Hydrolase
Nucleus
Reference proteome
tRNA processing

GWAS Trait Find Similar Targets

No Header	No Header
aspartate aminotransferase measurement
body mass index
erythrocyte count
heel bone mineral density
hematocrit
hemoglobin measurement
low density lipoprotein cholesterol measurement
mitochondrial heteroplasmy measurement
platelet count
platelet crit

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Rat	ribonuclease P/MRP subunit p14	RGD:1305436	361020
Dog	ribonuclease P/MRP subunit p14		612771
Horse	ribonuclease P/MRP subunit p14		100630485
Cow	ribonuclease P/MRP subunit p14		515208
Opossum	ribonuclease P/MRP subunit p14		100014407

Species	Name	OMA	EggNOG	Inparanoid
Rat	ribonuclease P/MRP subunit p14
Dog	ribonuclease P/MRP subunit p14
Horse	ribonuclease P/MRP subunit p14
Cow	ribonuclease P/MRP subunit p14
Opossum	ribonuclease P/MRP subunit p14

Publication Statistics

PubMed Score 8.04

PubMed score by year

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PubTator Score 414.88

PubTator score by year

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Related Publications

Text Mined References (18)

GeneRif Annotations (1)

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10

0 of 0

PMID	Year	Title