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Tbio
RPP14
Ribonuclease P protein subunit p14

Protein Summary
Description
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. This gene encodes a subunit of ribonuclease P and has 3' to 5' exoribonuclease activity. Transcripts for this gene are bicistronic and include a conserved downstream open reading frame for the hydroxyacyl-thioester dehydratase type 2 (HTD2) gene. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295959
  • ENSP00000295959
  • ENSG00000163684
  • ENST00000445193
  • ENSP00000412894
  • ENST00000466547
  • ENSP00000419909

Symbol
  • P14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
transcription factor binding site profile
0.89
virus perturbation
0.83
kinase perturbation
0.81
cell type or tissue
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.04   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.04   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (129)
RPP30
Tbio
Family:  Enzyme
Novelty:  0.01375777
p_int:  0.999999744
p_ni:  2.56e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
POP5
Tbio
Family:  Enzyme
Novelty:  0.02459167
p_int:  0.999998447
p_ni:  0.000001547
p_wrong:  6e-9
Score:  0.995
Data Source:  BioPlex,STRINGDB
C18orf21
Tdark
Novelty:  0.65363998
p_int:  0.999986681
p_ni:  0.000009127
p_wrong:  0.000004192
Score:  0.855
Data Source:  BioPlex,STRINGDB
RPP25L
Tdark
Family:  Enzyme
Novelty:  1.39761189
p_int:  0.999986601
p_ni:  0.000013396
p_wrong:  3e-9
Score:  0.699
Data Source:  BioPlex,STRINGDB
RPP21
Tbio
Family:  Enzyme
Novelty:  0.05805689
p_int:  0.999970786
p_ni:  0.000009761
p_wrong:  0.000019454
Score:  0.997
Data Source:  BioPlex,STRINGDB
POP4
Tbio
Family:  Enzyme
Novelty:  0.01072287
p_int:  0.999967821
p_ni:  0.000020738
p_wrong:  0.000011441
Score:  0.998
Data Source:  BioPlex,STRINGDB
RPP25
Tbio
Family:  Enzyme
Novelty:  0.07178063
p_int:  0.999875329
p_ni:  0.00012467
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
NEPRO
Tbio
Novelty:  0.12980261
p_int:  0.999737001
p_ni:  0.000103964
p_wrong:  0.000159036
Score:  0.344
Data Source:  BioPlex,STRINGDB
RPP40
Tbio
Family:  Enzyme
Novelty:  0.05981624
Score:  0.997
Data Source:  STRINGDB
RPP38
Tbio
Family:  Enzyme
Novelty:  0.06387902
Score:  0.993
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA processing
rRNA processing in the nucleus and cytosol
tRNA processing
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
2
2
88
low density lipoprotein cholesterol measurement
3
4
4
87.5
platelet count
2
2
2
82.5
aspartate aminotransferase measurement
1
1
0
13.3
82.5
red blood cell density measurement
1
1
1
77.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
88
low density lipoprotein cholesterol measurement
4
87.5
platelet count
2
82.5
aspartate aminotransferase measurement
0
13.3
82.5
red blood cell density measurement
1
77.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Rat
RGD:1305436
361020
Dog
ribonuclease P/MRP subunit p14
612771
Horse
ribonuclease P/MRP subunit p14
100630485
Cow
ribonuclease P/MRP subunit p14
515208
Opossum
ribonuclease P/MRP subunit p14
100014407
Species
Name
OMA
EggNOG
Inparanoid
Rat
Dog
ribonuclease P/MRP subunit p14
Horse
ribonuclease P/MRP subunit p14
Cow
ribonuclease P/MRP subunit p14
Opossum
ribonuclease P/MRP subunit p14
Publication Statistics
PubMed Score 8.04
PubMed score by year
PubTator Score 414.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title