RPP14
Ribonuclease P protein subunit p14
Protein Summary
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. This gene encodes a subunit of ribonuclease P and has 3' to 5' exoribonuclease activity. Transcripts for this gene are bicistronic and include a conserved downstream open reading frame for the hydroxyacyl-thioester dehydratase type 2 (HTD2) gene. [provided by RefSeq, May 2017]
- ENST00000295959
- ENSP00000295959
- ENSG00000163684
- ENST00000445193
- ENSP00000412894
- ENST00000466547
- ENSP00000419909
- P14
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.9 | ||
transcription factor binding site profile | 0.89 | ||
virus perturbation | 0.83 | ||
kinase perturbation | 0.81 | ||
cell type or tissue | 0.71 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.04 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 71 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.04 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 71 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
vitamin D measurement | 1 | 1 | 1 | 46.2 | |||||
3 | 1 | 1 | 1.2 | 36.3 | |||||
total cholesterol measurement | 1 | 1 | 1 | 21.4 | |||||
platelet count | 1 | 1 | 1 | 7 | |||||
platelet crit | 1 | 1 | 1 | 6.2 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
vitamin D measurement | 1 | 46.2 | |||||
1 | 1.2 | 36.3 | |||||
total cholesterol measurement | 1 | 21.4 | |||||
platelet count | 1 | 7 | |||||
platelet crit | 1 | 6.2 | |||||
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Rat | RGD:1305436 | 361020 | ||||||
Dog | ribonuclease P/MRP subunit p14 | 612771 | ||||||
Horse | ribonuclease P/MRP subunit p14 | 100630485 | ||||||
Cow | ribonuclease P/MRP subunit p14 | 515208 | ||||||
Opossum | ribonuclease P/MRP subunit p14 | 100014407 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Rat | ||||||
Dog | ribonuclease P/MRP subunit p14 | |||||
Horse | ribonuclease P/MRP subunit p14 | |||||
Cow | ribonuclease P/MRP subunit p14 | |||||
Opossum | ribonuclease P/MRP subunit p14 | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (7)
Reactome (6)
KEGG (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 6
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Major pathway of rRNA processing in the nucleolus and cytosol | ||||
Reactome | Metabolism of RNA | ||||
Reactome | rRNA processing | ||||
Reactome | rRNA processing in the nucleus and cytosol | ||||
Reactome | tRNA processing | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Major pathway of rRNA processing in the nucleolus and cytosol | ||||
Metabolism of RNA | ||||
rRNA processing | ||||
rRNA processing in the nucleus and cytosol | ||||
tRNA processing | ||||
Gene Ontology Terms (6)
Functions (2)
Components (3)
Processes (1)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Protein-Protein Interactions (129)
1 – 10 of 129
RPP30
Family: Enzyme
Novelty: 0.01375777
p_int: 0.999999744
p_ni: 2.56e-7
Score: 0.998
Data Source: BioPlex,STRINGDB
POP5
Family: Enzyme
Novelty: 0.02459167
p_int: 0.999998447
p_ni: 0.000001547
p_wrong: 6e-9
Score: 0.995
Data Source: BioPlex,STRINGDB
C18orf21
Novelty: 0.65363998
p_int: 0.999986681
p_ni: 0.000009127
p_wrong: 0.000004192
Score: 0.855
Data Source: BioPlex,STRINGDB
RPP25L
Family: Enzyme
Novelty: 1.39761189
p_int: 0.999986601
p_ni: 0.000013396
p_wrong: 3e-9
Score: 0.699
Data Source: BioPlex,STRINGDB
RPP21
Family: Enzyme
Novelty: 0.05805689
p_int: 0.999970786
p_ni: 0.000009761
p_wrong: 0.000019454
Score: 0.997
Data Source: BioPlex,STRINGDB
POP4
Family: Enzyme
Novelty: 0.01072287
p_int: 0.999967821
p_ni: 0.000020738
p_wrong: 0.000011441
Score: 0.998
Data Source: BioPlex,STRINGDB
RPP25
Family: Enzyme
Novelty: 0.07178063
p_int: 0.999875329
p_ni: 0.00012467
p_wrong: 1e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
NEPRO
Novelty: 0.12980261
p_int: 0.999737001
p_ni: 0.000103964
p_wrong: 0.000159036
Score: 0.344
Data Source: BioPlex,STRINGDB
RPP40
Family: Enzyme
Novelty: 0.05981624
Score: 0.997
Data Source: STRINGDB
RPP38
Family: Enzyme
Novelty: 0.06387902
Score: 0.993
Data Source: STRINGDB
Publication Statistics
PubMed Score 8.04
PubMed score by year
PubTator Score 414.88
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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