Tbio DIRAS1 GTP-binding protein Di-Ras1

Protein Summary

Description

Displays low GTPase activity and exists predominantly in the GTP-bound form. DIRAS1 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomeric GTPases.[supplied by OMIM, Apr 2004]

Uniprot Accession IDs

• O95057

Gene Name

• DIRAS1

Ensembl ID

• ENST00000323469
• ENSP00000325836
• ENSG00000176490
• ENST00000585334
• ENSP00000468417

Symbol

• GBTS1
• RIG
• RIG
• GBTS1
• Di-Ras1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
protein domain	0.58
histone modification site profile	0.52
tissue sample	0.48
biological process	0.47

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Gtp-binding Protein Di-ras1

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Gtp-binding Protein Di-ras1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.72   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 217   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.72   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0