Tchem INMT Indolethylamine N-methyltransferase

Protein Summary

Description

Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation of tryptamine and structurally related compounds. N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream FAM188B (family with sequence similarity 188, member B) gene. [provided by RefSeq, Nov 2010]

Uniprot Accession IDs

• O95050
• B8ZZ69
• Q3KP49
• Q9P1Y2
• Q9UBY4
• Q9UHQ0
• Indolamine N-methyltransferase

Gene Name

• INMT

Ensembl ID

• ENST00000013222
• ENSP00000013222
• ENSG00000241644
• ENST00000409539
• ENSP00000386961

Symbol

• TEMT

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.87
small molecule perturbation	0.71
kinase perturbation	0.48
tissue sample	0.47
chemical	0.46

Protein Classes

PANTHER Classes

Protein / Transferase / Methyltransferase / Indolethylamine N-methyltransferase

DTO Classes

Protein / Enzyme / Transferase / Methyltransferase / Indolethylamine N-methyltransferase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.24   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 139   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.24   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0