Tbio UPP2 Uridine phosphorylase 2

Protein Summary

Description

Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates.

Uniprot Accession IDs

• O95045
• B3KV87
• UPase 2

Gene Name

• UPP2

Ensembl ID

• ENST00000005756
• ENSP00000005756
• ENSG00000007001
• ENST00000605860
• ENSP00000474090

Symbol

• UP2
• UPASE2
• UDRPASE2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.71
gene perturbation	0.62
protein domain	0.58
transcription factor	0.58
microRNA	0.51

Protein Classes

PANTHER Classes

Protein / Transferase / Phosphorylase / Uridine Phosphorylase 2

DTO Classes

Protein / Enzyme / Transferase / Phosphorylase / Uridine Phosphorylase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.64   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 113   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.64   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0