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Tbio
SEMA3D
Semaphorin-3D

Protein Summary
Description
Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin (By similarity). This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin like domain and a C-terminal basic domain. The protein encoded by this gene binds neuropilin and plays an important role in cardiovascular development. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284136
  • ENSP00000284136
  • ENSG00000153993

Symbol
  • coll-2
  • Sema-Z2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
virus perturbation
0.79
cell line
0.63
cell type or tissue
0.58
microRNA
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.62   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.62   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
1
1
85.5
red blood cell density measurement
1
1
1
56.9
hemoglobin measurement
1
1
1
52.9
lymphocyte count
1
1
1
51.9
bone density
1
1
1
50.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
85.5
red blood cell density measurement
1
56.9
hemoglobin measurement
1
52.9
lymphocyte count
1
51.9
bone density
1
50.3
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (85)
1 – 10 of 85
SEMA3C
Tbio
Novelty: 0.00828813
p_int: 0.999999711
p_ni: 7.1e-8
p_wrong: 2.18e-7
Data Source: BioPlex
NRP1
Tchem
Novelty: 0.00153628
Score: 0.971
Data Source: STRINGDB
PLXNA1
Tbio
Novelty: 0.01195083
Score: 0.964
Data Source: STRINGDB
PLXNA3
Tbio
Novelty: 0.02016528
Score: 0.964
Data Source: STRINGDB
PLXNA4
Tbio
Novelty: 0.01807048
Score: 0.964
Data Source: STRINGDB
PLXND1
Tbio
Novelty: 0.01249713
Score: 0.915
Data Source: STRINGDB
PLXNB1
Tbio
Novelty: 0.01073808
Score: 0.914
Data Source: STRINGDB
PLXNC1
Tbio
Novelty: 0.02179837
Score: 0.912
Data Source: STRINGDB
PLXNB3
Tbio
Novelty: 0.02948198
Score: 0.912
Data Source: STRINGDB
PLXNB2
Tbio
Novelty: 0.01925055
Score: 0.899
Data Source: STRINGDB
Publication Statistics
PubMed Score  117.62

PubMed score by year
PubTator Score  23.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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