You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SOX30
Transcription factor SOX-30

Protein Summary
Description
Transcriptional activator. Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif. This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein acts as a transcriptional regulator when present in a complex with other proteins. It can activate p53 transcription to promote tumor cell apoptosis in lung cancer. The protein may be involved in the differentiation of developing male germ cells. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Apr 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265007
  • ENSP00000265007
  • ENSG00000039600
  • ENST00000311371
  • ENSP00000309343
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.77
disease perturbation
0.62
PubMedID
0.62
cell type or tissue
0.59
histone modification site profile
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.31   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.31   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
1
1
38.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
38.1
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SRY-box 30
VGNC:13596
462224
Mouse
MGI:1341157
214105
Dog
SRY-box 30
VGNC:46680
479316
Horse
SRY-box 30
VGNC:23461
100071201
Cow
SRY-box 30
VGNC:35148
538232
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SRY-box 30
Mouse
Dog
SRY-box 30
Horse
SRY-box 30
Cow
SRY-box 30
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O94993-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (28)
1 – 10 of 28
POU2F1
Tbio
Family: TF
Novelty: 0.00722164
Score: 0.768
Data Source: STRINGDB
ZNF274
Tbio
Family: TF
Novelty: 0.01432522
Score: 0.694
Data Source: STRINGDB
TSGA10
Tbio
Novelty: 0.04928862
Score: 0.65
Data Source: STRINGDB
THG1L
Tbio
Family: Enzyme
Novelty: 0.17339179
Score: 0.613
Data Source: STRINGDB
NUDT3
Tbio
Family: Enzyme
Novelty: 0.06052313
Score: 0.605
Data Source: STRINGDB
FHL5
Tbio
Novelty: 0.27618006
Score: 0.589
Data Source: STRINGDB
BAMBI
Tbio
Novelty: 0.00736806
Score: 0.547
Data Source: STRINGDB
FAM71B
Tdark
Novelty: 0.78218068
Score: 0.495
Data Source: STRINGDB
C10orf82
Tdark
Novelty: 7.20110868
Score: 0.494
Data Source: STRINGDB
POU5F1
Tbio
Family: TF
Novelty: 0.00033974
Score: 0.494
Data Source: STRINGDB
Publication Statistics
PubMed Score  29.31

PubMed score by year
PubTator Score  12.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer