Tbio CEP152 Centrosomal protein of 152 kDa

Protein Summary

Description

Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation (PubMed:21059844, PubMed:20852615). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615). This gene encodes a protein that is thought to be involved with centrosome function. Mutations in this gene have been associated with primary microcephaly (MCPH4). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]

Uniprot Accession IDs

• O94986
• E7ER66
• Q17RV1
• Q6NTA0
• Cep152

Gene Name

• CEP152

Ensembl ID

• ENST00000325747
• ENSP00000321000
• ENSG00000103995
• ENST00000380950
• ENSP00000370337
• ENST00000399334
• ENSP00000382271

Symbol

• KIAA0912
• MCPH4
• MCPH9
• SCKL5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.89
hub protein	0.71
tissue sample	0.68
cell line	0.67
transcription factor binding site profile	0.65

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Centrosomal Protein Of 152 Kda

DTO Classes

Protein / Signaling / Centrosomal Protein Of 152 Kda

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.31   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 163   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.31   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0