SEC31A
Protein transport protein Sec31A
Protein Summary
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple ...more
- ENST00000311785
- ENSP00000309070
- ENSG00000138674
- ENST00000348405
- ENSP00000337602
- ENST00000355196
- ENSP00000347329
- ENST00000395310
- ENSP00000378721
- ENST00000443462
- ENSP00000408027
- ENST00000448323
- ENSP00000400926
- ENST00000500777
- ENSP00000421464
- ENST00000505984
- ENSP00000424451
- ENST00000508502
- ENSP00000424635
- ENST00000509142
- ENSP00000426569
- ENST00000513858
- ENSP00000426886
- KIAA0905
- SEC31L1
- ABP125
- ABP130
- HSPC275
- HSPC334
- SEC31L1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.99 | ||
ligand (protein) perturbation | 0.83 | ||
biological process | 0.82 | ||
cellular component | 0.81 | ||
interacting protein | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 30.77 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 130 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 30.77 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 130 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0