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Tbio
SEC31A
Protein transport protein Sec31A

Protein Summary
Description
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311785
  • ENSP00000309070
  • ENSG00000138674
  • ENST00000348405
  • ENSP00000337602
  • ENST00000355196
  • ENSP00000347329
  • ENST00000395310
  • ENSP00000378721
  • ENST00000443462
  • ENSP00000408027
  • ENST00000448323
  • ENSP00000400926
  • ENST00000500777
  • ENSP00000421464
  • ENST00000505984
  • ENSP00000424451
  • ENST00000508502
  • ENSP00000424635
  • ENST00000509142
  • ENSP00000426569
  • ENST00000513858
  • ENSP00000426886

Symbol
  • KIAA0905
  • SEC31L1
  • ABP125
  • ABP130
  • HSPC275
  • HSPC334
  • SEC31L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
ligand (protein) perturbation
0.83
biological process
0.82
cellular component
0.81
interacting protein
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.73   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.73   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
2
2
2
80.3
hematocrit
2
2
2
78.7
red blood cell density measurement
1
1
1
78.3
lymphocyte count
1
1
1
69.3
erythrocyte count
2
2
2
64.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
2
80.3
hematocrit
2
78.7
red blood cell density measurement
1
78.3
lymphocyte count
1
69.3
erythrocyte count
2
64.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SEC31 homolog A, COPII coat complex component
VGNC:7054
461210
Macaque
SEC31 homolog A, COPII coat complex component
693687
Mouse
MGI:1916412
69162
Rat
RGD:620233
93646
Dog
SEC31 homolog A, COPII coat complex component
VGNC:45976
478453
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SEC31 homolog A, COPII coat complex component
Macaque
SEC31 homolog A, COPII coat complex component
Mouse
Rat
Dog
SEC31 homolog A, COPII coat complex component
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O94979-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (26)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
Class I MHC mediated antigen processing & presentation
Gene Ontology Terms (23)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (270)
1 – 10 of 270
SCYL1
Tbio
Family:  Kinase
Novelty:  0.03774351
p_int:  1
Score:  0.948
Data Source:  BioPlex,STRINGDB
TFG
Tbio
Novelty:  0.00320616
p_int:  0.999660019
p_ni:  0.000339981
Score:  0.984
Data Source:  BioPlex,Reactome,STRINGDB
SEC13
Tbio
Novelty:  0.00709413
p_int:  0.999093127
p_ni:  0.000906873
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
NOP14
Tbio
Novelty:  0.08903014
p_int:  0.998814873
p_ni:  0.001185127
Score:  0.202
Data Source:  BioPlex,STRINGDB
SEC23IP
Tbio
Novelty:  0.0925721
p_int:  0.996415007
p_ni:  0.003584993
Score:  0.977
Data Source:  BioPlex,Reactome,STRINGDB
NOC4L
Tdark
Novelty:  0.39929311
p_int:  0.996188114
p_ni:  0.003811884
p_wrong:  2e-9
Score:  0.2
Data Source:  BioPlex,STRINGDB
GNPDA1
Tbio
Family:  Enzyme
Novelty:  0.01296167
p_int:  0.977411954
p_ni:  0.022588046
Score:  0.234
Data Source:  BioPlex,STRINGDB
CCDC88A
Tbio
Novelty:  0.01077253
p_int:  0.844100842
p_ni:  0.155899158
Score:  0.175
Data Source:  BioPlex,STRINGDB
SEC23A
Tbio
Novelty:  0.0384262
Score:  0.999
Data Source:  Reactome,STRINGDB
SEC24B
Tbio
Novelty:  0.01031644
Score:  0.998
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  26.73

PubMed score by year
PubTator Score  23.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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