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Tbio
AP2A2
AP-2 complex subunit alpha-2

Protein Summary
Description
Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to pl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332231
  • ENSP00000327694
  • ENSG00000183020
  • ENST00000448903
  • ENSP00000413234
  • ENST00000528815
  • ENSP00000431630

Symbol
  • ADTAB
  • CLAPA2
  • HIP9
  • HYPJ
  • KIAA0899
  • HIP9
  • HYPJ
  • ADTAB
  • HIP-9
  • CLAPA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
protein domain
1
interacting protein
0.98
transcription factor perturbation
0.96
virus perturbation
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.47   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.47   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (286)
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.999998918
p_ni:  0.000001082
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
NECAP2
Tdark
Novelty:  0.4141034
p_int:  0.999998885
p_ni:  0.000001115
Score:  0.978
Data Source:  BioPlex,STRINGDB
AP2S1
Tbio
Novelty:  0.01931502
p_int:  0.99999692
p_ni:  0.00000308
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
EPS15L1
Tbio
Novelty:  0.06929299
p_int:  0.999988719
p_ni:  0.000011282
Score:  0.965
Data Source:  BioPlex,STRINGDB
AMPH
Tbio
Novelty:  0.00201043
p_int:  0.999965988
p_ni:  0.000034012
Score:  0.972
Data Source:  BioPlex,STRINGDB
CCDC32
Tdark
Novelty:  1.80929769
p_int:  0.999948433
p_ni:  0.000051568
Data Source:  BioPlex
AAGAB
Tbio
Novelty:  0.0479209
p_int:  0.999702592
p_ni:  0.000297408
Score:  0.719
Data Source:  BioPlex,STRINGDB
RUNDC3A
Tdark
Novelty:  0.23296904
p_int:  0.999451716
p_ni:  0.000548284
Score:  0.778
Data Source:  BioPlex,STRINGDB
ARFGAP1
Tbio
Family:  Enzyme
Novelty:  0.02654081
p_int:  0.99839535
p_ni:  0.00160465
Score:  0.966
Data Source:  BioPlex,STRINGDB
SNX9
Tbio
Novelty:  0.01737783
p_int:  0.99236415
p_ni:  0.00763585
Score:  0.928
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (54)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 44
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Axon guidance
Reactome
Beta-catenin independent WNT signaling
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Axon guidance
Beta-catenin independent WNT signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.5
92.7
mean platelet volume
2
2
2
79.8
heel bone mineral density
1
1
1
75.1
body fat distribution
1
1
1
56.1
body height
1
1
1
51.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.5
92.7
mean platelet volume
2
79.8
heel bone mineral density
1
75.1
body fat distribution
1
56.1
body height
1
51.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 2 subunit alpha 2
VGNC:11258
450939
Macaque
adaptor related protein complex 2 alpha 2 subunit
720875
Mouse
MGI:101920
11772
Rat
RGD:71015
81637
Dog
adaptor related protein complex 2 subunit alpha 2
VGNC:37959
475994
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 2 subunit alpha 2
Macaque
adaptor related protein complex 2 alpha 2 subunit
Mouse
Rat
Dog
adaptor related protein complex 2 subunit alpha 2
Publication Statistics
PubMed Score 13.47
PubMed score by year
PubTator Score 11.61
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title