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Tbio
TRIM37
E3 ubiquitin-protein ligase TRIM37

Protein Summary
Description
E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724). This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262294
  • ENSP00000262294
  • ENSG00000108395
  • ENST00000393065
  • ENSP00000376784
  • ENST00000393066
  • ENSP00000376785

Symbol
  • KIAA0898
  • MUL
  • POB1
  • MUL
  • POB1
  • TEF3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
histone modification site profile
0.91
molecular function
0.88
disease perturbation
0.87
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.44   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 204   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.44   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
2
1
2
69.9
self reported educational attainment
1
1
1
66.7
intelligence
1
1
0
7.6
51.1
mean corpuscular volume
1
1
1
41.6
mean reticulocyte volume
1
1
1
38
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
2
69.9
self reported educational attainment
1
66.7
intelligence
0
7.6
51.1
mean corpuscular volume
1
41.6
mean reticulocyte volume
1
38
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Gene Ontology Terms (21)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (326)
1 – 10 of 326
ZNF816
Tdark
Family: TF
Novelty: 0.59861195
p_int: 0.999994719
p_ni: 0.000005267
p_wrong: 1.4e-8
Score: 0.208
Data Source: BioPlex,STRINGDB
BORCS6
Tdark
Novelty: 0.83789033
p_int: 0.99998799
p_ni: 0.000012006
p_wrong: 5e-9
Score: 0.204
Data Source: BioPlex,STRINGDB
ZNF610
Tdark
Family: TF
Novelty: 1.33582282
p_int: 0.999986652
p_ni: 0.000013348
Score: 0.229
Data Source: BioPlex,STRINGDB
ZNF550
Tdark
Family: TF
Novelty: 18
p_int: 0.998923964
p_ni: 0.001059484
p_wrong: 0.000016552
Score: 0.169
Data Source: BioPlex,STRINGDB
ZNF554
Tdark
Family: TF
Novelty: 1.57478216
p_int: 0.998894369
p_ni: 0.000812141
p_wrong: 0.000293489
Data Source: BioPlex
DISC1
Tbio
Novelty: 0.00183442
p_int: 0.995388607
p_ni: 0.004609478
p_wrong: 0.000001916
Data Source: BioPlex
ZNF74
Tbio
Family: TF
Novelty: 0.10554307
p_int: 0.993552187
p_ni: 0.00641349
p_wrong: 0.000034324
Data Source: BioPlex
PI15
Tbio
Family: Enzyme
Novelty: 0.02244161
p_int: 0.991216303
p_ni: 0.008035367
p_wrong: 0.00074833
Data Source: BioPlex
NCAPH2
Tbio
Novelty: 0.12134933
p_int: 0.98456814
p_ni: 0.015425784
p_wrong: 0.000006077
Data Source: BioPlex
ZNF263
Tbio
Family: TF
Novelty: 0.098799
p_int: 0.980570624
p_ni: 0.019420757
p_wrong: 0.000008619
Score: 0.156
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  51.44

PubMed score by year
PubTator Score  52.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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