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Tchem
SLCO2B1
Solute carrier organic anion transporter family member 2B1

Protein Summary
Description
Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. This locus encodes a member of the organic anion-transporting polypeptide family of membrane proteins. The protein encoded by this locus may function in regulation of placental uptake of sulfated steroids. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000428359
  • ENSP00000388912
  • ENSG00000137491
  • ENST00000454962
  • ENSP00000389653

Symbol
  • KIAA0880
  • OATP2B1
  • OATPB
  • SLC21A9
  • OATPB
  • OATP-B
  • OATP2B1
  • SLC21A9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
0.97
cell type or tissue
0.68
transcription factor
0.67
disease perturbation
0.62
cell line
0.61


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 189.32   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 189.32   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
erlotinib
chemical structure image
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier organic anion transporter family member 2B1
VGNC:3050
466711
Macaque
solute carrier organic anion transporter family member 2B1
694829
Mouse
MGI:1351872
101488
Rat
RGD:621391
140860
Dog
solute carrier organic anion transporter family member 2B1
VGNC:46496
485192
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier organic anion transporter family member 2B1
Macaque
solute carrier organic anion transporter family member 2B1
Mouse
Rat
Dog
solute carrier organic anion transporter family member 2B1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O94956-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (23)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of organic anions
Reactome
Transport of small molecules
Reactome
Transport of vitamins, nucleosides, and related molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Transport of organic anions
Transport of small molecules
Transport of vitamins, nucleosides, and related molecules
Protein-Protein Interactions (59)
1 – 10 of 59
C1QB
Tbio
Novelty: 0.01476497
Score: 0.74
Data Source: STRINGDB
SLC10A1
Tchem
Family: Transporter
Novelty: 0.00142951
Score: 0.738
Data Source: STRINGDB
ABCG2
Tchem
Family: Transporter
Novelty: 0.00029779
Score: 0.717
Data Source: STRINGDB
SLC22A8
Tclin
Family: Transporter
Novelty: 0.00291642
Score: 0.714
Data Source: STRINGDB
SLC22A7
Tbio
Family: Transporter
Novelty: 0.00964024
Score: 0.714
Data Source: STRINGDB
C1QA
Tbio
Novelty: 0.00987917
Score: 0.702
Data Source: STRINGDB
ABCC3
Tbio
Family: Transporter
Novelty: 0.00260166
Score: 0.695
Data Source: STRINGDB
ABCC2
Tchem
Family: Transporter
Novelty: 0.00110828
Score: 0.69
Data Source: STRINGDB
SLC15A1
Tchem
Family: Transporter
Novelty: 0.00149723
Score: 0.689
Data Source: STRINGDB
SLC22A9
Tbio
Family: Transporter
Novelty: 0.02212992
Score: 0.681
Data Source: STRINGDB
Publication Statistics
PubMed Score  189.32

PubMed score by year
PubTator Score  123.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer