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Tbio
RHOBTB3
Rho-related BTB domain-containing protein 3

Protein Summary
Description
Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9. RHOBTB3 is a member of the evolutionarily conserved RHOBTB subfamily of Rho GTPases. For background information on RHOBTBs, see RHOBTB1 (MIM 607351).[supplied by OMIM, Apr 2004]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379982
  • ENSP00000369318
  • ENSG00000164292

Symbol
  • KIAA0878
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
molecular function
0.98
transcription factor binding site profile
0.86
PubMedID
0.85
kinase perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.79   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.79   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
3
14
81.2
reticulocyte measurement
3
2
6
66.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
14
81.2
reticulocyte measurement
6
66.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho related BTB domain containing 3
VGNC:8636
461743
Macaque
Rho related BTB domain containing 3
702554
Mouse
MGI:1920546
73296
Rat
RGD:1311683
309922
Dog
Rho related BTB domain containing 3
VGNC:53200
100687706
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho related BTB domain containing 3
Macaque
Rho related BTB domain containing 3
Mouse
Rat
Dog
Rho related BTB domain containing 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O94955-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Reactome
Retrograde transport at the Trans-Golgi-Network
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
Retrograde transport at the Trans-Golgi-Network
Vesicle-mediated transport
Gene Ontology Terms (20)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (94)
1 – 10 of 94
CUL3
Tbio
Novelty: 0.0028737
p_int: 0.999437995
p_ni: 0.000562005
Score: 0.584
Data Source: BioPlex,STRINGDB
NRG1
Tbio
Novelty: 0.00095246
p_int: 0.99907238
p_ni: 0.000927619
p_wrong: 2e-9
Score: 0.17
Data Source: BioPlex,STRINGDB
RABGGTB
Tbio
Family: Enzyme
Novelty: 0.06786314
p_int: 0.999036084
p_ni: 0.000963869
p_wrong: 4.6e-8
Score: 0.268
Data Source: BioPlex,STRINGDB
OPALIN
Tdark
Novelty: 0.08221612
p_int: 0.99819969
p_ni: 0.001799599
p_wrong: 7.12e-7
Data Source: BioPlex
FAS
Tbio
Novelty: 0.00043286
p_int: 0.997702597
p_ni: 0.002297274
p_wrong: 1.28e-7
Data Source: BioPlex
CA6
Tclin
Family: Enzyme
Novelty: 0.00293722
p_int: 0.995268753
p_ni: 0.004730619
p_wrong: 6.28e-7
Data Source: BioPlex
FURIN
Tchem
Family: Enzyme
Novelty: 0.00055079
p_int: 0.99495582
p_ni: 0.005044
p_wrong: 1.8e-7
Data Source: BioPlex
HAVCR2
Tbio
Novelty: 0.00155885
p_int: 0.991996632
p_ni: 0.007964932
p_wrong: 0.000038436
Data Source: BioPlex
ZP2
Tbio
Novelty: 0.00310166
p_int: 0.989776008
p_ni: 0.009008907
p_wrong: 0.001215085
Data Source: BioPlex
ISLR
Tbio
Novelty: 0.02936208
p_int: 0.983254207
p_ni: 0.016727185
p_wrong: 0.000018607
Score: 0.198
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  12.79

PubMed score by year
PubTator Score  5.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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