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Tdark
ABLIM3
Actin-binding LIM protein 3

Protein Summary
Description
May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. This gene encodes a member of the actin-binding LIM (abLIM) family of proteins. These proteins are characterized by an N-terminal LIM domain and a C-terminal dematin-like domain. The encoded protein interacts with actin filaments and may be a component of adherens junctions in several cell types. A variant of this gene may be associated with pain sensitivity in male human patients. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309868
  • ENSP00000310309
  • ENSG00000173210
  • ENST00000326685
  • ENSP00000315841
  • ENST00000504238
  • ENSP00000421183
  • ENST00000506113
  • ENSP00000425394
  • ENST00000517451
  • ENSP00000430150

Symbol
  • KIAA0843
  • HMFN1661
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.86
tissue sample
0.74
biological process
0.66
transcription factor binding site profile
0.64
microRNA
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.02   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.02   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
forced expiratory volume
2
2
2
74
BMI-adjusted waist-hip ratio
1
1
1
59.5
vital capacity
1
1
1
33.1
glomerular filtration rate
1
1
1
30.2
electrocardiography
1
1
2
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
forced expiratory volume
2
74
BMI-adjusted waist-hip ratio
1
59.5
vital capacity
1
33.1
glomerular filtration rate
1
30.2
electrocardiography
2
21.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
actin binding LIM protein family member 3
VGNC:3887
741703
Macaque
actin binding LIM protein family member 3
709180
Mouse
MGI:2442582
319713
Rat
RGD:1565118
307395
Dog
actin binding LIM protein family member 3
VGNC:37480
612309
Species
Name
OMA
EggNOG
Inparanoid
Chimp
actin binding LIM protein family member 3
Macaque
actin binding LIM protein family member 3
Mouse
Rat
Dog
actin binding LIM protein family member 3
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O94929-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
DCC mediated attractive signaling
Reactome
Developmental Biology
Reactome
Netrin-1 signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
DCC mediated attractive signaling
Developmental Biology
Netrin-1 signaling
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (50)
1 – 10 of 50
BRCA1
Tchem
Novelty:  0.00011146
p_int:  0.999887057
p_ni:  0.000079891
p_wrong:  0.000033053
Data Source:  BioPlex
BBS9
Tbio
Novelty:  0.01879869
p_int:  0.999632348
p_ni:  0.000367646
p_wrong:  7e-9
Data Source:  BioPlex
CCNH
Tbio
Novelty:  0.00693072
p_int:  0.998359206
p_ni:  0.001640746
p_wrong:  4.8e-8
Data Source:  BioPlex
AFDN
Tbio
Novelty:  0.00372947
p_int:  0.99672116
p_ni:  0.003278793
p_wrong:  4.7e-8
Data Source:  BioPlex
LIMD1
Tbio
Novelty:  0.04868333
p_int:  0.995464331
p_ni:  0.004500546
p_wrong:  0.000035123
Data Source:  BioPlex
PDLIM7
Tbio
Novelty:  0.00544518
p_int:  0.966068454
p_ni:  0.033931466
p_wrong:  8e-8
Data Source:  BioPlex
MNAT1
Tbio
Family:  Enzyme
Novelty:  0.02484936
p_int:  0.916421747
p_ni:  0.083574632
p_wrong:  0.00000362
Data Source:  BioPlex
BBS2
Tbio
Novelty:  0.00835161
p_int:  0.845277218
p_ni:  0.154722779
p_wrong:  3e-9
Data Source:  BioPlex
TARBP1
Tbio
Family:  Enzyme
Novelty:  0.04886897
p_int:  0.79861179
p_ni:  0.201382159
p_wrong:  0.000006051
Data Source:  BioPlex
UBR1
Tbio
Family:  Enzyme
Novelty:  0.00998888
p_int:  0.770486967
p_ni:  0.229513033
Data Source:  BioPlex
Publication Statistics
PubMed Score  4.02

PubMed score by year
PubTator Score  2.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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