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Tchem
GLS
Glutaminase kidney isoform, mitochondrial

Protein Classes
Protein Summary
Description
Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity. This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320717
  • ENSP00000317379
  • ENSG00000115419
  • ENST00000338435
  • ENSP00000340689

Symbol
  • GLS1
  • KIAA0838
  • GAC
  • GAM
  • KGA
  • GLS1
  • AAD20
  • CASGID
  • EIEE71
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
transcription factor perturbation
0.98
small molecule perturbation
0.9
transcription factor binding site profile
0.85
kinase perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 344.23   (req: < 5)
Gene RIFs: 62   (req: <= 3)
Antibodies: 392   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 344.23   (req: >= 5)
Gene RIFs: 62   (req: > 3)
Antibodies: 392   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 496
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
1
1
47.4
reticulocyte count
2
1
2
47.3
reticulocyte measurement
2
1
2
46.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
47.4
reticulocyte count
2
47.3
reticulocyte measurement
2
46.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutaminase
VGNC:443
470606
Mouse
MGI:95752
14660
Rat
RGD:2707
24398
Dog
glutaminase
VGNC:41276
488448
Horse
glutaminase [Source:HGNC Symbol;Acc:HGNC:4331]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutaminase
Mouse
Rat
Dog
glutaminase
Horse
glutaminase [Source:HGNC Symbol;Acc:HGNC:4331]
Protein Structure (23 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O94925-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 23
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (25)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Glutamate Neurotransmitter Release Cycle
Reactome
Glutamate and glutamine metabolism
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Glutamate Neurotransmitter Release Cycle
Glutamate and glutamine metabolism
Metabolism
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (154)
1 – 10 of 154
COL20A1
Tdark
Novelty: 0.39788946
p_int: 0.999995342
p_ni: 0.000004658
p_wrong: 1e-9
Data Source: BioPlex
PI15
Tbio
Family: Enzyme
Novelty: 0.02244161
p_int: 0.999961534
p_ni: 0.000038466
Data Source: BioPlex
CCL22
Tbio
Novelty: 0.00245992
p_int: 0.995906026
p_ni: 0.004093974
Data Source: BioPlex
NDUFS7
Tclin
Family: Enzyme
Novelty: 0.01562198
p_int: 0.990357956
p_ni: 0.00964103
p_wrong: 0.000001014
Score: 0.15
Data Source: BioPlex,STRINGDB
HMGCL
Tbio
Family: Enzyme
Novelty: 0.02741994
p_int: 0.974574539
p_ni: 0.025425443
p_wrong: 1.8e-8
Score: 0.163
Data Source: BioPlex,STRINGDB
SNRNP27
Tbio
Novelty: 0.0175187
p_int: 0.971506223
p_ni: 0.028493777
Data Source: BioPlex
CFAP45
Tbio
Novelty: 0.12173319
p_int: 0.965273245
p_ni: 0.034726755
Score: 0.416
Data Source: BioPlex,STRINGDB
TRMT61B
Tbio
Family: Enzyme
Novelty: 0.32929047
p_int: 0.922051708
p_ni: 0.077948292
p_wrong: 1e-9
Score: 0.181
Data Source: BioPlex,STRINGDB
TNF
Tclin
Novelty: 0.00001457
p_int: 0.914274149
p_ni: 0.08572584
p_wrong: 1.1e-8
Score: 0.36
Data Source: BioPlex,STRINGDB
MRPL43
Tdark
Novelty: 0.22331841
p_int: 0.90434402
p_ni: 0.095655887
p_wrong: 9.4e-8
Score: 0.232
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  344.23

PubMed score by year
PubTator Score  180.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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