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Tchem
CDK14
Cyclin-dependent kinase 14

Protein Summary
Description
Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport. PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265741
  • ENSP00000265741
  • ENSG00000058091
  • ENST00000380050
  • ENSP00000369390
  • ENST00000406263
  • ENSP00000385034

Symbol
  • KIAA0834
  • PFTK1
  • PFTK1
  • PFTAIRE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
PubMedID
0.86
virus perturbation
0.85
transcription factor perturbation
0.84
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.89   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.89   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
60.6
1
1
0
1.3
60.6
pulse pressure measurement
1
1
1
53.5
hair color
1
1
0
1.2
13.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
60.6
0
1.3
60.6
pulse pressure measurement
1
53.5
hair color
0
1.2
13.5
Protein-Protein Interactions (169)
1 – 10 of 169
ELL3
Tbio
Family: Enzyme
Novelty: 0.18245631
p_int: 0.999954382
p_ni: 0.000045618
Score: 0.186
Data Source: BioPlex,STRINGDB
ICK
Tchem
Family: Kinase
Novelty: 0.00810476
p_int: 0.995331539
p_ni: 0.000075454
p_wrong: 0.004593007
Score: 0.401
Data Source: BioPlex,STRINGDB
CDKN1A
Tbio
Family: Enzyme
Novelty: 0.00033009
p_int: 0.990600844
p_ni: 0.006402042
p_wrong: 0.002997115
Score: 0.86
Data Source: BioPlex,STRINGDB
FGR
Tchem
Family: Kinase
Novelty: 0.00262848
p_int: 0.989239332
p_ni: 3.2e-7
p_wrong: 0.010760348
Score: 0.37
Data Source: BioPlex,STRINGDB
CDK17
Tchem
Family: Kinase
Novelty: 0.25046297
p_int: 0.940793492
p_ni: 0.059206508
Score: 0.26
Data Source: BioPlex,STRINGDB
GDE1
Tbio
Family: Enzyme
Novelty: 0.05854843
p_int: 0.934136961
p_ni: 0.056269606
p_wrong: 0.009593433
Score: 0.311
Data Source: BioPlex,STRINGDB
CDK5
Tchem
Family: Kinase
Novelty: 0.00071394
p_int: 0.933373342
p_ni: 0.023351378
p_wrong: 0.04327528
Score: 0.218
Data Source: BioPlex,STRINGDB
HSP90AA5P
Tdark
p_int: 0.906179503
p_ni: 0.093820497
Data Source: BioPlex
CDKL2
Tchem
Family: Kinase
Novelty: 0.0669719
p_int: 0.826747418
p_ni: 0.131795384
p_wrong: 0.041457198
Score: 0.311
Data Source: BioPlex,STRINGDB
CCNY
Tbio
Novelty: 0.01400663
Score: 0.995
Data Source: STRINGDB
Publication Statistics
PubMed Score  56.89

PubMed score by year
PubTator Score  30.85

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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