You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NFAT5
Nuclear factor of activated T-cells 5

Protein Summary
Description
Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349945
  • ENSP00000338806
  • ENSG00000102908
  • ENST00000354436
  • ENSP00000346420
  • ENST00000393742
  • ENSP00000377343
  • ENST00000426654
  • ENSP00000413126
  • ENST00000566899
  • ENSP00000455628
  • ENST00000567239
  • ENSP00000457593
  • ENST00000627621
  • ENSP00000486610

Symbol
  • KIAA0827
  • TONEBP
  • NFATZ
  • OREBP
  • NF-AT5
  • NFATL1
  • TONEBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.97
transcription factor perturbation
0.96
protein domain
0.92
co-expressed gene
0.89
microRNA
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.97   (req: < 5)
Gene RIFs: 77   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.97   (req: >= 5)
Gene RIFs: 77   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
2
1
93.3
visceral adipose tissue measurement
1
1
1
92.7
heel bone mineral density
2
1
2
76.5
osteoarthritis, knee
1
1
0
1.1
70.4
body height
1
1
1
57.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
93.3
visceral adipose tissue measurement
1
92.7
heel bone mineral density
2
76.5
osteoarthritis, knee
0
1.1
70.4
body height
1
57.9
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
nuclear factor of activated T-cells 5
705518
Mouse
MGI:1859333
54446
Rat
RGD:1309142
307820
Dog
nuclear factor of activated T cells 5
VGNC:43765
489734
Horse
nuclear factor of activated T cells 5
VGNC:20702
100067190
Species
Name
OMA
EggNOG
Inparanoid
Macaque
nuclear factor of activated T-cells 5
Mouse
Rat
Dog
nuclear factor of activated T cells 5
Horse
nuclear factor of activated T cells 5
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O94916-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (18)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (78)
1 – 10 of 78
AKR1B1
Tclin
Family: Enzyme
Novelty: 0.00045769
Score: 0.817
Data Source: STRINGDB
SLC6A6
Tbio
Family: Transporter
Novelty: 0.00333868
Score: 0.802
Data Source: STRINGDB
JUN
Tchem
Family: TF
Novelty: 0.00006856
Score: 0.767
Data Source: STRINGDB
S100A4
Tbio
Novelty: 0.00136919
Score: 0.726
Data Source: STRINGDB
IL2
Tchem
Novelty: 0.00003129
Score: 0.703
Data Source: STRINGDB
IL4
Tbio
Novelty: 0.00005852
Score: 0.687
Data Source: STRINGDB
SLC6A12
Tchem
Family: Transporter
Novelty: 0.00751471
Score: 0.669
Data Source: STRINGDB
MAPK8
Tchem
Family: Kinase
Novelty: 0.00055723
Score: 0.669
Data Source: STRINGDB
REL
Tbio
Family: TF
Novelty: 0.00038265
Score: 0.654
Data Source: STRINGDB
SLC5A3
Tbio
Family: Transporter
Novelty: 0.01687313
Score: 0.648
Data Source: STRINGDB
Publication Statistics
PubMed Score  301.97

PubMed score by year
PubTator Score  138.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: