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Tbio
PCF11
Pre-mRNA cleavage complex 2 protein Pcf11

Protein Summary
Description
Component of pre-mRNA cleavage complex II. The protein encoded by this gene binds to CLP1 to form pre-mRNA cleavage factor IIm. The encoded protein is necessary for efficient Pol II transcription termination and may be involved in degradation of the 3' product of polyA site cleavage. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298281
  • ENSP00000298281
  • ENSG00000165494

Symbol
  • KIAA0824
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.83
transcription factor binding site profile
0.83
cell type or tissue
0.79
interacting protein
0.76
virus perturbation
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.64   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.64   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
1
31.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PCF11, cleavage and polyadenylation factor subunit
VGNC:1093
451458
Macaque
PCF11 cleavage and polyadenylation factor subunit
704490
Mouse
MGI:1919579
74737
Rat
RGD:1563397
361605
Dog
PCF11, cleavage and polyadenylation factor subunit
VGNC:44299
476786
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PCF11, cleavage and polyadenylation factor subunit
Macaque
PCF11 cleavage and polyadenylation factor subunit
Mouse
Rat
Dog
PCF11, cleavage and polyadenylation factor subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O94913-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
Processing of Capped Intronless Pre-mRNA
Reactome
Processing of Intronless Pre-mRNAs
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
Processing of Capped Intronless Pre-mRNA
Processing of Intronless Pre-mRNAs
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (320)
1 – 10 of 320
CDKN2AIP
Tbio
Novelty:  0.15331029
p_int:  0.999999997
p_ni:  2e-9
Score:  0.237
Data Source:  BioPlex,STRINGDB
CPSF2
Tbio
Novelty:  0.0510853
Score:  0.999
Data Source:  STRINGDB
FIP1L1
Tbio
Novelty:  0.00520044
Score:  0.998
Data Source:  STRINGDB
CLP1
Tbio
Family:  Enzyme
Novelty:  0.04643806
Score:  0.997
Data Source:  Reactome,STRINGDB
CSTF3
Tbio
Novelty:  0.05260909
Score:  0.997
Data Source:  STRINGDB
CSTF2
Tbio
Novelty:  0.01389909
Score:  0.996
Data Source:  STRINGDB
NUDT21
Tbio
Novelty:  0.02174736
Score:  0.995
Data Source:  Reactome,STRINGDB
SYMPK
Tbio
Novelty:  0.01773552
Score:  0.994
Data Source:  STRINGDB
CPSF1
Tbio
Novelty:  0.04396897
Score:  0.994
Data Source:  STRINGDB
CPSF3
Tchem
Novelty:  0.01880576
Score:  0.994
Data Source:  STRINGDB
Publication Statistics
PubMed Score  60.64

PubMed score by year
PubTator Score  13.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer