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Tbio
ADGRL1
Adhesion G protein-coupled receptor L1

Protein Summary
Description
Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity). This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340736
  • ENSP00000340688
  • ENSG00000072071
  • ENST00000361434
  • ENSP00000355328

Symbol
  • KIAA0821
  • LEC2
  • LPHN1
  • CL1
  • LEC2
  • CIRL1
  • LPHN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
disease perturbation
0.98
transcription factor perturbation
0.74
kinase perturbation
0.71
tissue sample
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.81   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.81   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (21)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (255)
1 – 10 of 255
FLRT1
Tdark
Novelty: 0.3774664
p_int: 0.999487427
p_ni: 0.000512573
Score: 0.851
Data Source: BioPlex,STRINGDB
FAM189B
Tbio
Novelty: 0.62780269
p_int: 0.9981169
p_ni: 0.0018831
Data Source: BioPlex
PCDHGB1
Tdark
Novelty: 2
p_int: 0.997211711
p_ni: 0.002788289
Data Source: BioPlex
TMEM30B
Tbio
Novelty: 0.41265163
p_int: 0.996928846
p_ni: 0.003071153
p_wrong: 1e-9
Data Source: BioPlex
CLEC2D
Tbio
Novelty: 0.03470529
p_int: 0.993992666
p_ni: 0.006007334
Score: 0.182
Data Source: BioPlex,STRINGDB
LPCAT2
Tbio
Family: Enzyme
Novelty: 0.027861
p_int: 0.984717813
p_ni: 0.015282168
p_wrong: 1.9e-8
Data Source: BioPlex
ZNRF4
Tbio
Novelty: 0.18181818
p_int: 0.980116827
p_ni: 0.019883173
Data Source: BioPlex
B4GAT1
Tbio
Family: Enzyme
Novelty: 0.06386176
p_int: 0.979369926
p_ni: 0.020630074
Data Source: BioPlex
FAM189A2
Tdark
Novelty: 1.62162162
p_int: 0.968211987
p_ni: 0.031788009
p_wrong: 5e-9
Data Source: BioPlex
NRG1
Tbio
Novelty: 0.00114197
p_int: 0.968064349
p_ni: 0.031935574
p_wrong: 7.7e-8
Score: 0.162
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  70.81

PubMed score by year
PubTator Score  196.7

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer