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Tbio
PRPF6
Pre-mRNA-processing factor 6

Protein Summary
Description
Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:28781166, PubMed:21549338). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266079
  • ENSP00000266079
  • ENSG00000101161

Symbol
  • C20orf14
  • TOM
  • ANT1
  • Prp6
  • RP60
  • ANT-1
  • hPrp6
  • U5-102K
  • C20orf14
  • SNRNP102
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
hub protein
0.99
transcription factor binding site profile
0.93
disease perturbation
0.9
kinase perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.37   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.37   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (314)
CD2BP2
Tbio
Novelty:  0.01440995
p_int:  0.999512394
p_ni:  0.000487606
Score:  0.999
Data Source:  BioPlex,STRINGDB
DDX23
Tbio
Family:  Enzyme
Novelty:  0.03592096
p_int:  0.9967582
p_ni:  0.0032418
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPB
Tbio
Novelty:  0.01503535
p_int:  0.994429289
p_ni:  0.005570711
Score:  0.996
Data Source:  BioPlex,STRINGDB
SNRPGP15
Tdark
p_int:  0.993826566
p_ni:  0.006173434
Data Source:  BioPlex
TSSC4
Tdark
Novelty:  0.17064786
p_int:  0.993626262
p_ni:  0.006373738
Score:  0.862
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.993583447
p_ni:  0.006416553
Score:  0.998
Data Source:  BioPlex,STRINGDB
SNRNP40
Tbio
Novelty:  0.16791896
p_int:  0.993400572
p_ni:  0.006599428
Score:  0.999
Data Source:  BioPlex,STRINGDB
TXNL4A
Tbio
Novelty:  0.04677517
p_int:  0.991949496
p_ni:  0.008050504
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.984966843
p_ni:  0.015033157
Score:  0.99
Data Source:  BioPlex,STRINGDB
SNRPF
Tdark
Novelty:  0.17624854
p_int:  0.982840312
p_ni:  0.017159688
Score:  0.998
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Reactome
mRNA Splicing - Minor Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
7
7
90.9
waist-hip ratio
1
4
4
90
mean reticulocyte volume
1
2
2
89.7
mean platelet volume
2
2
3
88
mean corpuscular volume
1
2
2
86.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
7
90.9
waist-hip ratio
4
90
mean reticulocyte volume
2
89.7
mean platelet volume
3
88
mean corpuscular volume
2
86.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pre-mRNA processing factor 6
VGNC:6250
458425
Macaque
pre-mRNA processing factor 6
719351
Mouse
MGI:1922946
68879
Rat
RGD:1307103
366276
Dog
pre-mRNA processing factor 6
VGNC:45029
477289
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pre-mRNA processing factor 6
Macaque
pre-mRNA processing factor 6
Mouse
Rat
Dog
pre-mRNA processing factor 6
Publication Statistics
PubMed Score 34.37
PubMed score by year
PubTator Score 877.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title