Tbio ERLIN2 Erlin-2

Protein Summary

Description

Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:19240031, PubMed:17502376). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (PubMed:24217618). This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• O94905
• A0JLQ1
• A8K5S9
• B4DM38
• D3DSW0
• Q6NW21
• Q86VS6
• Q86W49

Gene Name

• ERLIN2

Ensembl ID

• ENST00000276461
• ENSP00000276461
• ENSG00000147475
• ENST00000335171
• ENSP00000335220
• ENST00000397228
• ENSP00000380405
• ENST00000518586
• ENSP00000427847
• ENST00000519638
• ENSP00000428112
• ENST00000523107
• ENSP00000473292
• ENST00000523887
• ENSP00000429903
• ENST00000648919
• ENSP00000497100

Symbol

• C8orf2
• SPFH2
• NET32
• SPFH2
• SPG18
• C8orf2
• Erlin-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
kinase perturbation	0.97
transcription factor perturbation	0.96
microRNA	0.91
transcription factor binding site profile	0.84

Protein Classes

DTO Classes

Derlin-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.22   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 234   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.22   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 234   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0