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Tbio
SUN1
SUN domain-containing protein 1

Protein Summary
Description
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton (PubMed:18039933, PubMed:18396275). The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration (By similarity). Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly (By similarity). Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis (By similarity). Helps to define the distribution of nuc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389574
  • ENSP00000374225
  • ENSG00000164828
  • ENST00000401592
  • ENSP00000384015
  • ENST00000403868
  • ENSP00000383947
  • ENST00000425407
  • ENSP00000392309
  • ENST00000452783
  • ENSP00000413439
  • ENST00000457378
  • ENSP00000395952

Symbol
  • KIAA0810
  • UNC84A
  • UNC84A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
transcription factor
0.9
cellular component
0.87
transcription factor binding site profile
0.85
transcription factor perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.16   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.16   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
68.3
self reported educational attainment
1
1
1
67.2
1
1
0
1
21.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
68.3
self reported educational attainment
1
67.2
0
1
21.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Sad1 and UNC84 domain containing 1
VGNC:4527
472263
Macaque
Sad1 and UNC84 domain containing 1
708786
Mouse
MGI:1924303
77053
Rat
RGD:1359142
360773
Dog
Sad1 and UNC84 domain containing 1
VGNC:46984
480806
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Sad1 and UNC84 domain containing 1
Macaque
Sad1 and UNC84 domain containing 1
Mouse
Rat
Dog
Sad1 and UNC84 domain containing 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O94901-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Meiosis
Reactome
Meiotic synapsis
Reactome
Reproduction
Name
Explore in Pharos
Explore in Source
Cell Cycle
Meiosis
Meiotic synapsis
Reproduction
Gene Ontology Terms (18)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (145)
1 – 10 of 145
DPEP1
Tclin
Family: Enzyme
Novelty: 0.00384946
p_int: 0.999992963
p_ni: 0.000007036
p_wrong: 1e-9
Data Source: BioPlex
TNFSF18
Tbio
Novelty: 0.01423949
p_int: 0.999974739
p_ni: 0.000025261
Data Source: BioPlex
CAPN6
Tbio
Novelty: 0.04489237
p_int: 0.999520965
p_ni: 0.000479035
Score: 0.177
Data Source: BioPlex,STRINGDB
TYW5
Tbio
Novelty: 0.1382439
p_int: 0.998259188
p_ni: 0.001740812
Data Source: BioPlex
TRIP6
Tbio
Novelty: 0.02183202
p_int: 0.996297833
p_ni: 0.003702166
Score: 0.16
Data Source: BioPlex,STRINGDB
TMEM106A
Tbio
Novelty: 0.32470607
p_int: 0.993854715
p_ni: 0.006145285
Data Source: BioPlex
SCARA3
Tbio
Novelty: 0.00621523
p_int: 0.988021675
p_ni: 0.011978325
Data Source: BioPlex
ZACN
Tchem
Family: IC
Novelty: 0.21891621
p_int: 0.962737717
p_ni: 0.03726227
p_wrong: 1.3e-8
Data Source: BioPlex
ZNF507
Tdark
Family: TF
Novelty: 1.0899905
p_int: 0.959565678
p_ni: 0.040434322
Score: 0.226
Data Source: BioPlex,STRINGDB
LRRTM1
Tbio
Novelty: 0.0409182
p_int: 0.953924833
p_ni: 0.046075109
p_wrong: 5.8e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  119.16

PubMed score by year
PubTator Score  48.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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