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Tbio
UBXN7
UBX domain-containing protein 7

Protein Summary
Description
Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296328
  • ENSP00000296328
  • ENSG00000163960

Symbol
  • KIAA0794
  • UBXD7
  • UBXD7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.87
protein domain
0.85
histone modification site profile
0.83
virus perturbation
0.72
microRNA
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.73   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 27   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.73   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
68.1
serum IgM measurement
1
1
1
47.9
mean corpuscular hemoglobin
1
1
1
41.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
68.1
serum IgM measurement
1
47.9
mean corpuscular hemoglobin
1
41.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
UBX domain protein 7
710083
Mouse
MGI:2146388
224111
Rat
RGD:6493076
100911374
Dog
UBX domain protein 7
VGNC:48102
488028
Horse
UBX domain protein 7
VGNC:24759
100069887
Species
Name
OMA
EggNOG
Inparanoid
Macaque
UBX domain protein 7
Mouse
Rat
Dog
UBX domain protein 7
Horse
UBX domain protein 7
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O94888-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Protein-Protein Interactions (430)
1 – 10 of 430
TCEANC2
Tdark
Novelty: 0.40325323
p_int: 0.999978276
p_ni: 0.000021724
p_wrong: 1e-9
Score: 0.691
Data Source: BioPlex,STRINGDB
RNF111
Tbio
Family: Enzyme
Novelty: 0.03059486
p_int: 0.999946139
p_ni: 0.000053861
Score: 0.882
Data Source: BioPlex,STRINGDB
TMEM31
Tdark
Novelty: 0.65381391
p_int: 0.999725926
p_ni: 0.000271863
p_wrong: 0.00000221
Data Source: BioPlex
FAM189B
Tbio
Novelty: 0.21064304
p_int: 0.99948267
p_ni: 0.000517228
p_wrong: 1.02e-7
Data Source: BioPlex
NUAK2
Tchem
Family: Kinase
Novelty: 0.02463599
p_int: 0.998702967
p_ni: 0.001296983
p_wrong: 5e-8
Score: 0.188
Data Source: BioPlex,STRINGDB
KCNK16
Tbio
Family: IC
Novelty: 0.09168043
p_int: 0.996738653
p_ni: 0.002594839
p_wrong: 0.000666508
Score: 0.217
Data Source: BioPlex,STRINGDB
ATG9A
Tbio
Novelty: 0.01995033
p_int: 0.993816635
p_ni: 0.005829183
p_wrong: 0.000354182
Score: 0.201
Data Source: BioPlex,STRINGDB
XKRX
Tdark
Novelty: 0.35938148
p_int: 0.993049038
p_ni: 0.00512302
p_wrong: 0.001827941
Score: 0.243
Data Source: BioPlex,STRINGDB
TGIF2LY
Tdark
Family: TF
p_int: 0.978928095
p_ni: 0.019916385
p_wrong: 0.00115552
Data Source: BioPlex
VCP
Tchem
Family: Enzyme
Novelty: 0.00103317
Score: 0.996
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.73

PubMed score by year
PubTator Score  4.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer