Tdark TMEM63A CSC1-like protein 1

Protein Summary

Description

Acts as an osmosensitive calcium-permeable cation channel.

Uniprot Accession IDs

• O94886
• Q53GI7
• Q5TE96
• Q8N2U2

Gene Name

• TMEM63A

Ensembl ID

• ENST00000366835
• ENSP00000355800
• ENSG00000196187

Symbol

• KIAA0489
• KIAA0792
• KIAA0792

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.85
transcription factor	0.72
transcription factor perturbation	0.68
kinase perturbation	0.66
cellular component	0.65

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.84   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 72   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.84   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

IDG Resources

Reagents (1)

Data Resources (1)

Cell

IDG-HEK293T-TMEM63A-V5-OE

Details:

• RRID: CVCL_YA82
• Species: Homo sapiens

Data:

• IDG-HEK293T-TMEM63A-V5-OE

Order Cell from:

UCSF

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	transmembrane protein 63A	VGNC:1689	457778
Macaque	transmembrane protein 63A		701499
Mouse	transmembrane protein 63a	MGI:2384789	208795
Rat	transmembrane protein 63a	RGD:1306829	289318
Dog	transmembrane protein 63A	VGNC:47595	490389

Species	Name	OMA	EggNOG	Inparanoid
Chimp	transmembrane protein 63A
Macaque	transmembrane protein 63A
Mouse	transmembrane protein 63a
Rat	transmembrane protein 63a
Dog	transmembrane protein 63A

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-O94886-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)

Reactome (3)

Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	Neutrophil degranulation	543 targets	R-HSA-6798695

Name	Explore in Pharos	Explore in Source
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249
Neutrophil degranulation	543 targets	R-HSA-6798695

Gene Ontology Terms (11)

Functions (2)

Components (8)

Processes (1)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
calcium activated cation channel activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
nucleic acid binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (178)

Explore Interacting Targets

1 – 10 of 178

• See Interactions on String-DB

AP3S2

Tdark

Novelty: 0.25186243

p_int: 0.999999802

p_ni: 1.95e-7

p_wrong: 3e-9

Score: 0.536

Data Source: BioPlex,STRINGDB

MFSD10

Tbio

Novelty: 0.12830664

p_int: 0.999999318

p_ni: 4.75e-7

p_wrong: 2.06e-7

Score: 0.205

Data Source: BioPlex,STRINGDB

AP3S1

Tbio

Novelty: 0.12425009

p_int: 0.999415788

p_ni: 0.000584212

p_wrong: 1e-9

Score: 0.206

Data Source: BioPlex,STRINGDB

AP3B1

Tbio

Novelty: 0.03117931

p_int: 0.99860298

p_ni: 0.00139702

Data Source: BioPlex

PTPN1

Tchem

Family: Enzyme

Novelty: 0.00065779

p_int: 0.998556131

p_ni: 0.001443869

Score: 0.211

Data Source: BioPlex,STRINGDB

LGALS3

Tchem

Novelty: 0.00032754

p_int: 0.991943564

p_ni: 0.008056436

Score: 0.267

Data Source: BioPlex,STRINGDB

ATP2B2

Tbio

Family: Transporter

Novelty: 0.007782

p_int: 0.990084049

p_ni: 0.009915951

Data Source: BioPlex

HTR3A

Tclin

Family: IC

Novelty: 0.00217443

p_int: 0.989114183

p_ni: 0.010885817

Data Source: BioPlex

YIPF4

Tdark

Novelty: 0.17862058

p_int: 0.98280861

p_ni: 0.017182704

p_wrong: 0.000008685

Data Source: BioPlex

LGALS8

Tchem

Novelty: 0.00623836

p_int: 0.982403663

p_ni: 0.017596337

Score: 0.387

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  3.84

PubMed score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Calcium
Complete proteome
Ion channel
Ion transport
Lysosome
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane