Tdark TMEM63A CSC1-like protein 1

Protein Summary

Description

Acts as an osmosensitive calcium-permeable cation channel.

Uniprot Accession IDs

• O94886
• Q53GI7
• Q5TE96
• Q8N2U2

Gene Name

• TMEM63A

Ensembl ID

• ENST00000366835
• ENSP00000355800
• ENSG00000196187

Symbol

• KIAA0489
• KIAA0792
• KIAA0792

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.85
transcription factor	0.72
transcription factor perturbation	0.68
kinase perturbation	0.66
cellular component	0.65

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.07   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 72   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.07   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (3)

Reactome (3)

Immune System (R-HSA-168256)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	Neutrophil degranulation	543 targets	R-HSA-6798695

Name	Explore in Pharos	Explore in Source
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249
Neutrophil degranulation	543 targets	R-HSA-6798695

Gene Ontology Terms (11)

Functions (2)

Components (8)

Processes (1)

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GO Term	Evidence	Assigned by
calcium activated cation channel activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
nucleic acid binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (178)

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1 – 10 of 178

• See Interactions on String-DB

AP3S2

Tdark

Novelty: 0.46657241

p_int: 0.999999802

p_ni: 1.95e-7

p_wrong: 3e-9

Score: 0.536

Data Source: BioPlex,STRINGDB

MFSD10

Tbio

Novelty: 0.00649456

p_int: 0.999999318

p_ni: 4.75e-7

p_wrong: 2.06e-7

Score: 0.205

Data Source: BioPlex,STRINGDB

AP3S1

Tbio

Novelty: 0.23622047

p_int: 0.999415788

p_ni: 0.000584212

p_wrong: 1e-9

Score: 0.206

Data Source: BioPlex,STRINGDB

AP3B1

Tbio

Novelty: 0.05716867

p_int: 0.99860298

p_ni: 0.00139702

Data Source: BioPlex

PTPN1

Tchem

Family: Enzyme

Novelty: 0.0007632

p_int: 0.998556131

p_ni: 0.001443869

Score: 0.211

Data Source: BioPlex,STRINGDB

LGALS3

Tchem

Novelty: 0.00032884

p_int: 0.991943564

p_ni: 0.008056436

Score: 0.267

Data Source: BioPlex,STRINGDB

ATP2B2

Tbio

Family: Transporter

Novelty: 0.00724828

p_int: 0.990084049

p_ni: 0.009915951

Data Source: BioPlex

HTR3A

Tclin

Family: IC

Novelty: 0.00035394

p_int: 0.989114183

p_ni: 0.010885817

Data Source: BioPlex

YIPF4

Tbio

Novelty: 0.06083159

p_int: 0.98280861

p_ni: 0.017182704

p_wrong: 0.000008685

Data Source: BioPlex

LGALS8

Tchem

Novelty: 0.00746585

p_int: 0.982403663

p_ni: 0.017596337

Score: 0.387

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  1.07

PubMed score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Calcium
Complete proteome
Ion channel
Ion transport
Lysosome
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane