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Tdark
TMEM63A
CSC1-like protein 1

Protein Summary
Description
Acts as an osmosensitive calcium-permeable cation channel.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366835
  • ENSP00000355800
  • ENSG00000196187

Symbol
  • KIAA0489
  • KIAA0792
  • KIAA0792
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.85
transcription factor
0.72
transcription factor perturbation
0.68
kinase perturbation
0.66
cellular component
0.65


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.84   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.84   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 63A
VGNC:1689
457778
Macaque
transmembrane protein 63A
701499
Mouse
MGI:2384789
208795
Rat
RGD:1306829
289318
Dog
transmembrane protein 63A
VGNC:47595
490389
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 63A
Macaque
transmembrane protein 63A
Mouse
Rat
Dog
transmembrane protein 63A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O94886-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (178)
1 – 10 of 178
AP3S2
Tdark
Novelty: 0.25186243
p_int: 0.999999802
p_ni: 1.95e-7
p_wrong: 3e-9
Score: 0.536
Data Source: BioPlex,STRINGDB
MFSD10
Tbio
Novelty: 0.12830664
p_int: 0.999999318
p_ni: 4.75e-7
p_wrong: 2.06e-7
Score: 0.205
Data Source: BioPlex,STRINGDB
AP3S1
Tbio
Novelty: 0.12425009
p_int: 0.999415788
p_ni: 0.000584212
p_wrong: 1e-9
Score: 0.206
Data Source: BioPlex,STRINGDB
AP3B1
Tbio
Novelty: 0.03117931
p_int: 0.99860298
p_ni: 0.00139702
Data Source: BioPlex
PTPN1
Tchem
Family: Enzyme
Novelty: 0.00065779
p_int: 0.998556131
p_ni: 0.001443869
Score: 0.211
Data Source: BioPlex,STRINGDB
LGALS3
Tchem
Novelty: 0.00032754
p_int: 0.991943564
p_ni: 0.008056436
Score: 0.267
Data Source: BioPlex,STRINGDB
ATP2B2
Tbio
Family: Transporter
Novelty: 0.007782
p_int: 0.990084049
p_ni: 0.009915951
Data Source: BioPlex
HTR3A
Tclin
Family: IC
Novelty: 0.00217443
p_int: 0.989114183
p_ni: 0.010885817
Data Source: BioPlex
YIPF4
Tdark
Novelty: 0.17862058
p_int: 0.98280861
p_ni: 0.017182704
p_wrong: 0.000008685
Data Source: BioPlex
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.982403663
p_ni: 0.017596337
Score: 0.387
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  3.84

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer