Protein Summary
Acts as an osmosensitive calcium-permeable cation channel.
- ENST00000366835
- ENSP00000355800
- ENSG00000196187
- KIAA0489
- KIAA0792
- KIAA0792
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.85 | ||
transcription factor | 0.72 | ||
transcription factor perturbation | 0.68 | ||
kinase perturbation | 0.66 | ||
cellular component | 0.65 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.84 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 72 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.84 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 72 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (178)
1 – 10 of 178
AP3S2
Novelty: 0.25186243
p_int: 0.999999802
p_ni: 1.95e-7
p_wrong: 3e-9
Score: 0.536
Data Source: BioPlex,STRINGDB
MFSD10
Novelty: 0.12830664
p_int: 0.999999318
p_ni: 4.75e-7
p_wrong: 2.06e-7
Score: 0.205
Data Source: BioPlex,STRINGDB
AP3S1
Novelty: 0.12425009
p_int: 0.999415788
p_ni: 0.000584212
p_wrong: 1e-9
Score: 0.206
Data Source: BioPlex,STRINGDB
AP3B1
Novelty: 0.03117931
p_int: 0.99860298
p_ni: 0.00139702
Data Source: BioPlex
PTPN1
Family: Enzyme
Novelty: 0.00065779
p_int: 0.998556131
p_ni: 0.001443869
Score: 0.211
Data Source: BioPlex,STRINGDB
LGALS3
Novelty: 0.00032754
p_int: 0.991943564
p_ni: 0.008056436
Score: 0.267
Data Source: BioPlex,STRINGDB
ATP2B2
Family: Transporter
Novelty: 0.007782
p_int: 0.990084049
p_ni: 0.009915951
Data Source: BioPlex
HTR3A
Family: IC
Novelty: 0.00217443
p_int: 0.989114183
p_ni: 0.010885817
Data Source: BioPlex
YIPF4
Novelty: 0.17862058
p_int: 0.98280861
p_ni: 0.017182704
p_wrong: 0.000008685
Data Source: BioPlex
LGALS8
Novelty: 0.00623836
p_int: 0.982403663
p_ni: 0.017596337
Score: 0.387
Data Source: BioPlex,STRINGDB
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 3 of 3
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Neutrophil degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Immune System | ||||
Innate Immune System | ||||
Neutrophil degranulation | ||||
Gene Ontology Terms (11)
Functions (2)
Components (8)
Processes (1)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
lymphocyte count | 2 | 2 | 2 | 71.2 | |||||
sex hormone-binding globulin measurement | 2 | 1 | 2 | 56.4 | |||||
mean corpuscular volume | 1 | 1 | 1 | 32.9 | |||||
red blood cell distribution width | 2 | 1 | 2 | 24.5 | |||||
platelet crit | 2 | 1 | 2 | 15.7 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
lymphocyte count | 2 | 71.2 | |||||
sex hormone-binding globulin measurement | 2 | 56.4 | |||||
mean corpuscular volume | 1 | 32.9 | |||||
red blood cell distribution width | 2 | 24.5 | |||||
platelet crit | 2 | 15.7 | |||||
Find similar targets by:
UniProt Keyword
No Header | No Header | ||
|---|---|---|---|
IDG Resources
Reagents (1)
Data Resources (1)
Cell
IDG-HEK293T-TMEM63A-V5-OE
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | transmembrane protein 63A | VGNC:1689 | 457778 | |||||
Macaque | transmembrane protein 63A | 701499 | ||||||
Mouse | MGI:2384789 | 208795 | ||||||
Rat | RGD:1306829 | 289318 | ||||||
Dog | transmembrane protein 63A | VGNC:47595 | 490389 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | transmembrane protein 63A | |||||
Macaque | transmembrane protein 63A | |||||
Mouse | ||||||
Rat | ||||||
Dog | transmembrane protein 63A | |||||
Publication Statistics
PubMed Score 4.84
PubMed score by year