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Tdark
TMEM63A
CSC1-like protein 1

Protein Summary
Description
Acts as an osmosensitive calcium-permeable cation channel.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366835
  • ENSP00000355800
  • ENSG00000196187

Symbol
  • KIAA0489
  • KIAA0792
  • KIAA0792
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.85
transcription factor
0.72
transcription factor perturbation
0.68
kinase perturbation
0.66
cellular component
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.07   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.07   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (178)
1 – 10 of 178
AP3S2
Tdark
Novelty: 0.46657241
p_int: 0.999999802
p_ni: 1.95e-7
p_wrong: 3e-9
Score: 0.536
Data Source: BioPlex,STRINGDB
MFSD10
Tbio
Novelty: 0.00649456
p_int: 0.999999318
p_ni: 4.75e-7
p_wrong: 2.06e-7
Score: 0.205
Data Source: BioPlex,STRINGDB
AP3S1
Tbio
Novelty: 0.23622047
p_int: 0.999415788
p_ni: 0.000584212
p_wrong: 1e-9
Score: 0.206
Data Source: BioPlex,STRINGDB
AP3B1
Tbio
Novelty: 0.05716867
p_int: 0.99860298
p_ni: 0.00139702
Data Source: BioPlex
PTPN1
Tchem
Family: Enzyme
Novelty: 0.0007632
p_int: 0.998556131
p_ni: 0.001443869
Score: 0.211
Data Source: BioPlex,STRINGDB
LGALS3
Tchem
Novelty: 0.00032884
p_int: 0.991943564
p_ni: 0.008056436
Score: 0.267
Data Source: BioPlex,STRINGDB
ATP2B2
Tbio
Family: Transporter
Novelty: 0.00724828
p_int: 0.990084049
p_ni: 0.009915951
Data Source: BioPlex
HTR3A
Tclin
Family: IC
Novelty: 0.00035394
p_int: 0.989114183
p_ni: 0.010885817
Data Source: BioPlex
YIPF4
Tbio
Novelty: 0.06083159
p_int: 0.98280861
p_ni: 0.017182704
p_wrong: 0.000008685
Data Source: BioPlex
LGALS8
Tchem
Novelty: 0.00746585
p_int: 0.982403663
p_ni: 0.017596337
Score: 0.387
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1.07

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer