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Tbio
SORBS2
Sorbin and SH3 domain-containing protein 2

Protein Summary
Description
Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284776
  • ENSP00000284776
  • ENSG00000154556
  • ENST00000319471
  • ENSP00000322182
  • ENST00000355634
  • ENSP00000347852
  • ENST00000393528
  • ENSP00000377162
  • ENST00000418609
  • ENSP00000397482
  • ENST00000437304
  • ENSP00000396008
  • ENST00000448662
  • ENSP00000409158
  • ENST00000449407
  • ENSP00000397262

Symbol
  • ARGBP2
  • KIAA0777
  • ARGBP2
  • PRO0618
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
PubMedID
0.84
transcription factor
0.71
molecular function
0.67
hub protein
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.62   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.62   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
VCL
Tbio
Novelty:  0.00043107
Score:  0.817
Data Source:  STRINGDB
EIF3H
Tbio
Novelty:  0.02564681
Score:  0.808
Data Source:  STRINGDB
CBL
Tbio
Family:  Enzyme
Novelty:  0.00114929
Score:  0.772
Data Source:  STRINGDB
ABL1
Tclin
Family:  Kinase
Novelty:  0.00023803
Score:  0.765
Data Source:  STRINGDB
VTA1
Tbio
Novelty:  0.01697854
Score:  0.755
Data Source:  STRINGDB
SHC2
Tbio
Novelty:  0.00219395
Score:  0.753
Data Source:  STRINGDB
GCH1
Tbio
Family:  Enzyme
Novelty:  0.0025793
Score:  0.739
Data Source:  STRINGDB
CAPN15
Tbio
Novelty:  0.01046841
Score:  0.739
Data Source:  STRINGDB
CCNK
Tbio
Novelty:  0.03528971
Score:  0.739
Data Source:  STRINGDB
PALLD
Tbio
Novelty:  0.01191944
Score:  0.673
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (24)
Find Similar Targets
Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Extracellular vesicles in the crosstalk of cardiac cells
WikiPathways
Extracellular vesicles in the crosstalk of cardiac cells
WikiPathways
Extracellular vesicles in the crosstalk of cardiac cells
WikiPathways
Extracellular vesicles in the crosstalk of cardiac cells
WikiPathways
Extracellular vesicles in the crosstalk of cardiac cells
Name
Explore in Pharos
Explore in Source
Extracellular vesicles in the crosstalk of cardiac cells
Extracellular vesicles in the crosstalk of cardiac cells
Extracellular vesicles in the crosstalk of cardiac cells
Extracellular vesicles in the crosstalk of cardiac cells
Extracellular vesicles in the crosstalk of cardiac cells
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
3
4
76.5
self reported educational attainment
1
1
1
51.7
2
1
2
40.7
IGF-1 measurement
1
1
1
33.1
body height
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
76.5
self reported educational attainment
1
51.7
2
40.7
IGF-1 measurement
1
33.1
body height
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
sorbin and SH3 domain containing 2
696139
Rat
RGD:620061
114901
Dog
sorbin and SH3 domain containing 2
VGNC:51827
482906
Horse
sorbin and SH3 domain containing 2
VGNC:23446
100050682
Species
Name
OMA
EggNOG
Inparanoid
Macaque
sorbin and SH3 domain containing 2
Rat
Dog
sorbin and SH3 domain containing 2
Horse
sorbin and SH3 domain containing 2
Publication Statistics
PubMed Score 54.62
PubMed score by year
PubTator Score 19.06
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title