Tbio SORBS2 Sorbin and SH3 domain-containing protein 2

Protein Summary

Description

Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O94875
• A6NEK9
• B3KPQ7
• B7Z1G5
• B7Z3X6
• C9JKV9
• D3DP62
• D3DP63
• E9PAS5
• E9PAW4
• G3XAI0
• H7BXR4
• J3KNZ5
• O60592
• O60593
• Q96EX0

Gene Name

• SORBS2

Ensembl ID

• ENST00000284776
• ENSP00000284776
• ENSG00000154556
• ENST00000319471
• ENSP00000322182
• ENST00000355634
• ENSP00000347852
• ENST00000393528
• ENSP00000377162
• ENST00000418609
• ENSP00000397482
• ENST00000437304
• ENSP00000396008
• ENST00000448662
• ENSP00000409158
• ENST00000449407
• ENSP00000397262

Symbol

• ARGBP2
• KIAA0777
• ARGBP2
• PRO0618

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.98
PubMedID	0.84
transcription factor	0.71
molecular function	0.67
hub protein	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.3   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 98   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.3   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0