Tbio NFASC Neurofascin

Protein Summary

Description

Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009]

Uniprot Accession IDs

• O94856
• B2RNN8
• B3KQZ1
• B5MDP6
• B5MDR6
• B7ZMD8
• Q149P5
• Q5T2F0
• Q5T2F1
• Q5T2F2
• Q5T2F3
• Q5T2F4
• Q5T2F5
• Q5T2F6
• Q5T2F7
• Q5T2F9
• Q5T2G0
• Q5W9F8
• Q68DH3
• Q6ZQV6
• Q7Z3K1
• Q96HT1
• Q96K50

Gene Name

• NFASC

Ensembl ID

• ENST00000339876
• ENSP00000344786
• ENSG00000163531
• ENST00000360049
• ENSP00000353154
• ENST00000401399
• ENSP00000385637
• ENST00000403080
• ENSP00000384875
• ENST00000404076
• ENSP00000385676
• ENST00000404907
• ENSP00000384061
• ENST00000513543
• ENSP00000425908
• ENST00000539706
• ENSP00000438614

Symbol

• KIAA0756
• NF
• NRCAML
• NEDCPMD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
microRNA	0.83
cellular component	0.78
transcription factor	0.76
virus perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.89   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 202   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.89   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0