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Tbio
SEC24D
Protein transport protein Sec24D

Protein Summary
Description
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:20427317, PubMed:18843296). Plays a central role in cargo selection within the COPII complex and together with SEC24C may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:20427317, PubMed:18843296). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296). The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280551
  • ENSP00000280551
  • ENSG00000150961

Symbol
  • KIAA0755
  • CLCRP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
protein domain
0.92
cellular component
0.79
histone modification site profile
0.75
pathway
0.65


Related Tools
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.35   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.35   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
SEC24 homolog D, COPII coat complex component
707521
Mouse
MGI:1916858
69608
Rat
RGD:1311720
310843
Dog
SEC24 homolog D, COPII coat complex component
VGNC:45975
478523
Horse
SEC24 homolog D, COPII coat complex component
VGNC:22795
100064058
Species
Name
OMA
EggNOG
Inparanoid
Macaque
SEC24 homolog D, COPII coat complex component
Mouse
Rat
Dog
SEC24 homolog D, COPII coat complex component
Horse
SEC24 homolog D, COPII coat complex component
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O94855-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (45)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
Cargo concentration in the ER
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
Cargo concentration in the ER
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (283)
1 – 10 of 283
SEC23B
Tbio
Novelty: 0.02307622
p_int: 0.999999442
p_ni: 5.58e-7
Score: 0.989
Data Source: BioPlex,STRINGDB
PLEKHO1
Tbio
Novelty: 0.01658553
p_int: 0.999561982
p_ni: 0.000437993
p_wrong: 2.5e-8
Score: 0.181
Data Source: BioPlex,STRINGDB
SLC13A2
Tbio
Family: Transporter
Novelty: 0.01020451
p_int: 0.987202172
p_ni: 0.012352984
p_wrong: 0.000444843
Score: 0.232
Data Source: BioPlex,STRINGDB
PLPPR2
Tdark
Family: Enzyme
Novelty: 1.03318406
p_int: 0.971423947
p_ni: 0.028236365
p_wrong: 0.000339688
Score: 0.218
Data Source: BioPlex,STRINGDB
AMTN
Tbio
Novelty: 0.02514528
p_int: 0.883337062
p_ni: 0.116113738
p_wrong: 0.0005492
Score: 0.221
Data Source: BioPlex,STRINGDB
TMA16
Tdark
Novelty: 0.89810617
p_int: 0.883337062
p_ni: 0.116113738
p_wrong: 0.0005492
Score: 0.189
Data Source: BioPlex,STRINGDB
IL17F
Tbio
Novelty: 0.00223549
p_int: 0.882226969
p_ni: 0.117773031
Data Source: BioPlex
SEC23A
Tbio
Novelty: 0.0384262
Score: 0.999
Data Source: Reactome,STRINGDB
SEC24A
Tbio
Novelty: 0.07724534
Score: 0.998
Data Source: Reactome,STRINGDB
SEC24C
Tbio
Novelty: 0.05842956
Score: 0.994
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  19.35

PubMed score by year
PubTator Score  13.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer