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Tbio
TOX4
TOX high mobility group box family member 4

Protein Summary
Description
Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000448790
  • ENSP00000393080
  • ENSG00000092203
  • ENST00000613569
  • ENSP00000477868

Symbol
  • C14orf92
  • KIAA0737
  • LCP1
  • MIG7
  • C14orf92
  • KIAA0737
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
histone modification site profile
0.91
transcription factor perturbation
0.88
ligand (protein) perturbation
0.83
transcription factor binding site profile
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.05   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.05   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
77.9
diet measurement
1
1
1
71.2
self reported educational attainment
1
1
1
59
BMI-adjusted hip circumference
1
1
1
47.7
smoking status measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
77.9
diet measurement
1
71.2
self reported educational attainment
1
59
BMI-adjusted hip circumference
1
47.7
smoking status measurement
1
15.8
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
TOX high mobility group box family member 4
706950
Mouse
MGI:1915389
268741
Rat
RGD:708449
286990
Dog
TOX high mobility group box family member 4
475403
Horse
TOX high mobility group box family member 4
VGNC:49365
100059448
Species
Name
OMA
EggNOG
Inparanoid
Macaque
TOX high mobility group box family member 4
Mouse
Rat
Dog
TOX high mobility group box family member 4
Horse
TOX high mobility group box family member 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O94842-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (98)
1 – 10 of 98
PPP1R10
Tbio
Family:  Enzyme
Novelty:  0.01119155
p_int:  0.999999849
p_ni:  1.49e-7
p_wrong:  2e-9
Score:  0.889
Data Source:  BioPlex,STRINGDB
TOX2
Tbio
Family:  TF
Novelty:  0.02511477
p_int:  0.995650932
p_ni:  0.004349068
Score:  0.332
Data Source:  BioPlex,STRINGDB
KLK7
Tchem
Family:  Enzyme
Novelty:  0.00757766
p_int:  0.981981684
p_ni:  0.018016414
p_wrong:  0.000001902
Score:  0.173
Data Source:  BioPlex,STRINGDB
IFNA1
Tbio
Novelty:  0.0000962
p_int:  0.981455961
p_ni:  0.014710585
p_wrong:  0.003833453
Data Source:  BioPlex
SERPINB8
Tbio
Novelty:  0.03308357
p_int:  0.977017565
p_ni:  0.022982435
Score:  0.167
Data Source:  BioPlex,STRINGDB
SERPINA12
Tbio
Novelty:  0.00549132
p_int:  0.96258446
p_ni:  0.037415538
p_wrong:  2e-9
Data Source:  BioPlex
CST6
Tbio
Novelty:  0.02811473
p_int:  0.939231037
p_ni:  0.06034179
p_wrong:  0.000427173
Score:  0.153
Data Source:  BioPlex,STRINGDB
A2ML1
Tbio
Novelty:  0.05923067
p_int:  0.903082498
p_ni:  0.096917304
p_wrong:  1.99e-7
Data Source:  BioPlex
KPRP
Tdark
Novelty:  0.11744927
p_int:  0.809524935
p_ni:  0.190131933
p_wrong:  0.000343132
Score:  0.175
Data Source:  BioPlex,STRINGDB
ALOX12B
Tbio
Family:  Enzyme
Novelty:  0.02778552
p_int:  0.76225072
p_ni:  0.23774928
Score:  0.175
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  45.05

PubMed score by year
PubTator Score  5.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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