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Tbio
DDHD2
Phospholipase DDHD2

Protein Summary
Description
Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane. This gene encodes a phospholipase enzyme containing sterile-alpha-motif (SAM), WWE, and DDHD domains. This protein participates in membrane trafficking between the endoplastic reticulum and the Golgi body. Mutations in this gene can cause autosomal recessive spastic paraplegia 54. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397166
  • ENSP00000380352
  • ENSG00000085788
  • ENST00000517385
  • ENSP00000429017
  • ENST00000520272
  • ENSP00000429932

Symbol
  • KIAA0725
  • SAMWD1
  • SPG54
  • SAMWD1
  • iPLA(1)gamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
histone modification site profile
0.78
microRNA
0.74
protein domain
0.73
virus perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.84   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.84   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (82)
TGM4
Tbio
Family:  Enzyme
Novelty:  0.01478178
p_int:  0.999988346
p_ni:  0.000011386
p_wrong:  2.69e-7
Score:  0.297
Data Source:  BioPlex,STRINGDB
EMILIN1
Tbio
Novelty:  0.02550566
p_int:  0.999976624
p_ni:  0.000023035
p_wrong:  3.41e-7
Data Source:  BioPlex
AARSD1
Tdark
Novelty:  0.75372406
p_int:  0.999933411
p_ni:  0.000066552
p_wrong:  3.7e-8
Data Source:  BioPlex
LRRC8E
Tbio
Novelty:  0.15689344
p_int:  0.999929739
p_ni:  0.000069966
p_wrong:  2.95e-7
Score:  0.173
Data Source:  BioPlex,STRINGDB
C2orf68
Tdark
Novelty:  0.7947239
p_int:  0.99989911
p_ni:  0.000100887
p_wrong:  3e-9
Score:  0.228
Data Source:  BioPlex,STRINGDB
BLVRA
Tbio
Family:  Enzyme
Novelty:  0.00526407
p_int:  0.999876658
p_ni:  0.000123308
p_wrong:  3.3e-8
Score:  0.2
Data Source:  BioPlex,STRINGDB
SEC23IP
Tbio
Novelty:  0.0925721
p_int:  0.999676945
p_ni:  0.000323055
Score:  0.548
Data Source:  BioPlex,STRINGDB
HSP90AA5P
Tdark
p_int:  0.998797444
p_ni:  0.001202555
p_wrong:  1e-9
Data Source:  BioPlex
ALOX5
Tclin
Family:  Enzyme
Novelty:  0.00062988
p_int:  0.998214822
p_ni:  0.00072367
p_wrong:  0.001061508
Data Source:  BioPlex
RAPGEF5
Tbio
Novelty:  0.02449802
p_int:  0.996616166
p_ni:  0.003380031
p_wrong:  0.000003803
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PA
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PA
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
88.2
systolic blood pressure
1
1
1
73
3
3
1
1.1
61.3
urate measurement
1
1
1
54.4
1
1
1
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
88.2
systolic blood pressure
1
73
1
1.1
61.3
urate measurement
1
54.4
1
26.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DDHD domain containing 2
VGNC:893
464117
Mouse
MGI:1919358
72108
Rat
RGD:1585818
680971
Dog
DDHD domain containing 2
VGNC:39833
475586
Horse
DDHD domain containing 2
VGNC:17073
100059244
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DDHD domain containing 2
Mouse
Rat
Dog
DDHD domain containing 2
Horse
DDHD domain containing 2
Publication Statistics
PubMed Score 25.84
PubMed score by year
PubTator Score 11.65
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title