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Tbio
SLIT2
Slit homolog 2 protein

Protein Summary
Description
Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for re ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000503823
  • ENSP00000427548
  • ENSG00000145147
  • ENST00000503837
  • ENSP00000422261
  • ENST00000504154
  • ENSP00000422591

Symbol
  • SLIL3
  • SLIL3
  • Slit-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
protein domain
1
PubMedID
0.98
molecular function
0.91
histone modification site profile
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.46   (req: < 5)
Gene RIFs: 111   (req: <= 3)
Antibodies: 297   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.46   (req: >= 5)
Gene RIFs: 111   (req: > 3)
Antibodies: 297   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
61.9
smoking status measurement
1
1
1
35
2
2
2
26.1
serum metabolite measurement
1
1
1
4.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
61.9
smoking status measurement
1
35
2
26.1
serum metabolite measurement
1
4.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
slit guidance ligand 2
VGNC:738
461137
Macaque
slit guidance ligand 2
715470
Mouse
MGI:1315205
20563
Dog
slit guidance ligand 2
VGNC:46504
595148
Horse
slit guidance ligand 2
VGNC:51322
100068338
Species
Name
OMA
EggNOG
Inparanoid
Chimp
slit guidance ligand 2
Macaque
slit guidance ligand 2
Mouse
Dog
slit guidance ligand 2
Horse
slit guidance ligand 2
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O94813-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Activation of RAC1 (R-HSA-428540)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of RAC1
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Inactivation of CDC42 and RAC1
Reactome
Netrin-1 signaling
Name
Explore in Pharos
Explore in Source
Activation of RAC1
Axon guidance
Developmental Biology
Inactivation of CDC42 and RAC1
Netrin-1 signaling
Gene Ontology Terms (53)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (132)
1 – 10 of 132
ANKRD12
Tbio
Novelty:  0.13114331
p_int:  0.954530617
p_ni:  0.045469383
Score:  0.28
Data Source:  BioPlex,STRINGDB
DEFA1
Tbio
Novelty:  0.01027492
p_int:  0.895342531
p_ni:  0.104657469
Data Source:  BioPlex
MSMB
Tbio
Novelty:  0.00241546
p_int:  0.850952158
p_ni:  0.149047842
Score:  0.214
Data Source:  BioPlex,STRINGDB
PRICKLE3
Tbio
Novelty:  0.26347141
p_int:  0.827077578
p_ni:  0.172922422
Score:  0.263
Data Source:  BioPlex,STRINGDB
PRG3
Tbio
Novelty:  0.09431986
p_int:  0.806917794
p_ni:  0.193082206
Score:  0.181
Data Source:  BioPlex,STRINGDB
ROBO1
Tbio
Novelty:  0.00494884
Score:  0.999
Data Source:  Reactome,STRINGDB
ROBO2
Tbio
Novelty:  0.00757203
Score:  0.996
Data Source:  Reactome,STRINGDB
DCC
Tbio
Novelty:  0.01273911
Score:  0.969
Data Source:  Reactome,STRINGDB
GPC1
Tbio
Novelty:  0.00293087
Score:  0.958
Data Source:  Reactome,STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.951
Data Source:  STRINGDB
Publication Statistics
PubMed Score  159.46

PubMed score by year
PubTator Score  139.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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