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Tbio
TPPP
Tubulin polymerization-promoting protein

Protein Summary
Description
May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360578
  • ENSP00000353785
  • ENSG00000171368

Symbol
  • TPPP1
  • p24
  • p25
  • TPPP1
  • TPPP/p25
  • p25alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
0.72
histone modification site profile
0.66
hub protein
0.63
cellular component
0.6
PubMedID
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.68   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 237   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.68   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
1
1
59
2
2
0
1.3
45.6
2
2
1
1.2
36.9
3
2
0
1.1
36.5
BMI-adjusted waist circumference
1
1
1
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
59
0
1.3
45.6
1
1.2
36.9
0
1.1
36.5
BMI-adjusted waist circumference
1
27.3
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1920198
72948
Rat
RGD:1310121
361466
Dog
tubulin polymerization promoting protein
VGNC:47749
488072
Horse
tubulin polymerization promoting protein
VGNC:24440
100146662
Cow
tubulin polymerization promoting protein
VGNC:36258
280968
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
tubulin polymerization promoting protein
Horse
tubulin polymerization promoting protein
Cow
tubulin polymerization promoting protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O94811-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Glial Cell Differentiation
WikiPathways
Glial Cell Differentiation
WikiPathways
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
WikiPathways
Regulation of Microtubule Cytoskeleton
Name
Explore in Pharos
Explore in Source
Glial Cell Differentiation
Glial Cell Differentiation
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
Regulation of Microtubule Cytoskeleton
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
HGNC
Protein-Protein Interactions (67)
1 – 10 of 67
C2orf27B
Tdark
Novelty:  4.24242424
p_int:  0.995668159
p_ni:  0.004331701
p_wrong:  1.41e-7
Score:  0.54
Data Source:  BioPlex,STRINGDB
HIST1H1A
Tbio
Novelty:  0.00123818
p_int:  0.994733039
p_ni:  0.005266688
p_wrong:  2.73e-7
Data Source:  BioPlex
FADD
Tbio
Novelty:  0.00137968
p_int:  0.97861864
p_ni:  0.02124587
p_wrong:  0.00013549
Score:  0.309
Data Source:  BioPlex,STRINGDB
GRPEL1
Tbio
Novelty:  0.00185346
p_int:  0.926881925
p_ni:  0.070823933
p_wrong:  0.002294142
Score:  0.332
Data Source:  BioPlex,STRINGDB
GAPDH
Tchem
Family:  Enzyme
Novelty:  0.00005849
Score:  0.93
Data Source:  STRINGDB
TUBA4A
Tchem
Novelty:  0.00820546
Score:  0.803
Data Source:  STRINGDB
GAPDHS
Tbio
Family:  Enzyme
Novelty:  0.00885959
Score:  0.732
Data Source:  STRINGDB
F12
Tchem
Family:  Enzyme
Novelty:  0.00143881
Score:  0.711
Data Source:  STRINGDB
SNCA
Tchem
Novelty:  0.00012042
Score:  0.682
Data Source:  STRINGDB
CDK5
Tchem
Family:  Kinase
Novelty:  0.00071394
Score:  0.667
Data Source:  STRINGDB
Publication Statistics
PubMed Score  163.68

PubMed score by year
PubTator Score  627.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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