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Tbio
GFPT2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

Protein Summary
Description
Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253778
  • ENSP00000253778
  • ENSG00000131459

Symbol
  • GFAT
  • GFAT2
  • GFAT 2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
gene perturbation
0.98
PubMedID
0.83
transcription factor perturbation
0.8
protein domain
0.73


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.79   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.79   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (102)
GFPT1
Tchem
Family:  Enzyme
Novelty:  0.00358283
p_int:  0.99998585
p_ni:  0.00001415
Score:  0.966
Data Source:  BioPlex,STRINGDB
ACOT9
Tbio
Family:  Enzyme
Novelty:  0.17405187
p_int:  0.999878799
p_ni:  0.000121201
Score:  0.207
Data Source:  BioPlex,STRINGDB
FIGNL1
Tbio
Family:  Enzyme
Novelty:  0.10817841
p_int:  0.996030561
p_ni:  0.003853361
p_wrong:  0.000116078
Score:  0.184
Data Source:  BioPlex,STRINGDB
SALL2
Tbio
Family:  TF
Novelty:  0.01181421
p_int:  0.951298007
p_ni:  0.048701993
Score:  0.2
Data Source:  BioPlex,STRINGDB
FDX2
Tdark
Novelty:  0.05747769
p_int:  0.914168743
p_ni:  0.017438462
p_wrong:  0.068392796
Score:  0.563
Data Source:  BioPlex,STRINGDB
ACYP2
Tbio
Family:  Enzyme
Novelty:  0.03063981
p_int:  0.875189787
p_ni:  0.124810213
Data Source:  BioPlex
LRP1
Tbio
Novelty:  0.00200788
p_int:  0.85457123
p_ni:  0.14542877
Score:  0.232
Data Source:  BioPlex,STRINGDB
SLAMF1
Tbio
Novelty:  0.00112892
p_int:  0.820256482
p_ni:  0.179743518
Data Source:  BioPlex
OSTM1
Tbio
Novelty:  0.03033192
p_int:  0.798316619
p_ni:  0.201683381
Data Source:  BioPlex
DKK3
Tbio
Novelty:  0.00519275
p_int:  0.789194083
p_ni:  0.210805917
Score:  0.205
Data Source:  BioPlex,STRINGDB
Pathways (16)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of UDP-N-acetyl-glucosamine
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins
Post-translational protein modification
Synthesis of UDP-N-acetyl-glucosamine
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
airway imaging measurement
1
1
1
46.9
body height
1
1
1
33.1
BMI-adjusted hip circumference
1
1
1
31.4
BMI-adjusted waist circumference
1
1
1
6.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
airway imaging measurement
1
46.9
body height
1
33.1
BMI-adjusted hip circumference
1
31.4
BMI-adjusted waist circumference
1
6.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutamine-fructose-6-phosphate transaminase 2
VGNC:4011
462337
Macaque
glutamine-fructose-6-phosphate transaminase 2
715826
Mouse
MGI:1338883
14584
Rat
RGD:1303097
360518
Dog
glutamine-fructose-6-phosphate transaminase 2
VGNC:41188
474653
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutamine-fructose-6-phosphate transaminase 2
Macaque
glutamine-fructose-6-phosphate transaminase 2
Mouse
Rat
Dog
glutamine-fructose-6-phosphate transaminase 2
Publication Statistics
PubMed Score 100.79
PubMed score by year
PubTator Score 8.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title