Tchem PRKD3 Serine/threonine-protein kinase D3

Protein Summary

Description

Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate cancer cells, and vesicle trafficking. [provided by RefSeq, Jan 2015]

Uniprot Accession IDs

• O94806
• D6W587
• Q53TR7
• Q8NEL8

Gene Name

• PRKD3

Ensembl ID

• ENST00000234179
• ENSP00000234179
• ENSG00000115825
• ENST00000379066
• ENSP00000368356

Symbol

• EPK2
• PRKCN
• EPK2
• PKD3
• PRKCN
• PKC-NU
• nPKC-NU

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
transcription factor perturbation	0.99
drug perturbation	0.96
molecular function	0.95
metabolite	0.82

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Pkd Family / Serine/threonine-protein Kinase D3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.17   (req: < 5)

Gene RIFs: 36   (req: <= 3)

Antibodies: 388   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.17   (req: >= 5)

Gene RIFs: 36   (req: > 3)

Antibodies: 388   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 30

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0