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Tchem
PRKD3
Serine/threonine-protein kinase D3

Protein Summary
Description
Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate cancer cells, and vesicle trafficking. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234179
  • ENSP00000234179
  • ENSG00000115825
  • ENST00000379066
  • ENSP00000368356

Symbol
  • EPK2
  • PRKCN
  • EPK2
  • PKD3
  • PRKCN
  • PKC-NU
  • nPKC-NU
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor perturbation
0.99
drug perturbation
0.96
molecular function
0.95
metabolite
0.82


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.86   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 388   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.86   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 388   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
1
1
43.5
lymphocyte percentage of leukocytes
1
1
1
26.3
neutrophil percentage of leukocytes
1
1
1
15.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
43.5
lymphocyte percentage of leukocytes
1
26.3
neutrophil percentage of leukocytes
1
15.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase D3
VGNC:342
459158
Macaque
protein kinase D3
709647
Mouse
MGI:1922542
75292
Rat
RGD:1310236
313834
Dog
protein kinase D3
VGNC:44988
483036
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase D3
Macaque
protein kinase D3
Mouse
Rat
Dog
protein kinase D3
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O94806-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid de novo biosynthesis
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Sphingolipid de novo biosynthesis
Sphingolipid metabolism
Protein-Protein Interactions (42)
1 – 10 of 42
PRKD2
Tchem
Family: Kinase
Novelty: 0.03143723
Score: 0.901
Data Source: STRINGDB
PRKCA
Tchem
Family: Kinase
Novelty: 0.00057611
Score: 0.818
Data Source: STRINGDB
RAP1A
Tchem
Family: Enzyme
Novelty: 0.00375413
Score: 0.815
Data Source: STRINGDB
PRKCB
Tchem
Family: Kinase
Novelty: 0.00189802
Score: 0.812
Data Source: STRINGDB
PRKCG
Tchem
Family: Kinase
Novelty: 0.00291817
Score: 0.808
Data Source: STRINGDB
PRKD1
Tchem
Family: Kinase
Novelty: 0.00128927
Score: 0.804
Data Source: STRINGDB
RAP1B
Tbio
Family: Enzyme
Novelty: 0.00627538
Score: 0.804
Data Source: STRINGDB
CREB3L2
Tbio
Family: TF
Novelty: 0.0284456
Score: 0.688
Data Source: STRINGDB
P2RY14
Tchem
Family: GPCR
Novelty: 0.0135462
Score: 0.646
Data Source: STRINGDB
CREB1
Tbio
Family: TF
Novelty: 0.00018059
Score: 0.628
Data Source: STRINGDB
Publication Statistics
PubMed Score  20.86

PubMed score by year
PubTator Score  9.43

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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