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Tchem
STK10
Serine/threonine-protein kinase 10

Protein Summary
Description
Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000176763
  • ENSP00000176763
  • ENSG00000072786

Symbol
  • LOK
  • LOK
  • PRO2729
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.99
molecular function
0.98
transcription factor binding site profile
0.93
kinase perturbation
0.88
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.83   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 261   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.83   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
83.9
heel bone mineral density
2
1
2
68.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
83.9
heel bone mineral density
2
68.7
Protein Data Bank (11)
1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Protein-Protein Interactions (108)
1 – 10 of 108
ERVMER34-1
Tdark
Novelty: 0.03871814
Score: 0.926
Data Source: STRINGDB
SLC44A2
Tbio
Family: Transporter
Novelty: 0.01550561
Score: 0.925
Data Source: STRINGDB
ITGB2
Tclin
Novelty: 0.00185859
Score: 0.914
Data Source: STRINGDB
ADAM8
Tchem
Family: Enzyme
Novelty: 0.00871246
Score: 0.91
Data Source: STRINGDB
ITGAL
Tclin
Novelty: 0.00099016
Score: 0.908
Data Source: STRINGDB
TNFRSF1B
Tbio
Novelty: 0.0013033
Score: 0.907
Data Source: STRINGDB
ITGAM
Tbio
Novelty: 0.00017521
Score: 0.906
Data Source: STRINGDB
MCEMP1
Tdark
Novelty: 0.14180782
Score: 0.905
Data Source: STRINGDB
HVCN1
Tchem
Family: IC
Novelty: 0.00195009
Score: 0.905
Data Source: STRINGDB
C3AR1
Tchem
Family: GPCR
Novelty: 0.00527301
Score: 0.905
Data Source: STRINGDB
Publication Statistics
PubMed Score  63.83

PubMed score by year
PubTator Score  108.49

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer