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Tbio
ALDH1A2
Retinal dehydrogenase 2

Protein Summary
Description
Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity). This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249750
  • ENSP00000249750
  • ENSG00000128918
  • ENST00000347587
  • ENSP00000309623
  • ENST00000537372
  • ENSP00000438296
  • ENST00000559517
  • ENSP00000453408

Symbol
  • RALDH2
  • RALDH2
  • RALDH2-T
  • RALDH(II)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.94
PubMedID
0.88
gene perturbation
0.85
protein domain
0.85
phenotype
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 232.99   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 326   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 232.99   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 326   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (48)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
33
32
98
2.3
99.9
vitamin D measurement
6
5
13
99.6
triglyceride measurement
21
17
54
3.3
99.5
low density lipoprotein cholesterol measurement
6
7
7
99.5
total cholesterol measurement
11
19
38
2.6
99.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
98
2.3
99.9
vitamin D measurement
13
99.6
triglyceride measurement
54
3.3
99.5
low density lipoprotein cholesterol measurement
7
99.5
total cholesterol measurement
38
2.6
99.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aldehyde dehydrogenase 1 family member A2
VGNC:3517
746847
Macaque
aldehyde dehydrogenase 1 family member A2
702235
Mouse
MGI:107928
19378
Rat
RGD:620250
116676
Dog
aldehyde dehydrogenase 1 family member A2
VGNC:37783
478319
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aldehyde dehydrogenase 1 family member A2
Macaque
aldehyde dehydrogenase 1 family member A2
Mouse
Rat
Dog
aldehyde dehydrogenase 1 family member A2
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O94788-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
RA biosynthesis pathway (R-HSA-5365859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RA biosynthesis pathway
Reactome
Signal Transduction
Reactome
Signaling by Nuclear Receptors
Reactome
Signaling by Retinoic Acid
Name
Explore in Pharos
Explore in Source
RA biosynthesis pathway
Signal Transduction
Signaling by Nuclear Receptors
Signaling by Retinoic Acid
Gene Ontology Terms (43)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (124)
1 – 10 of 124
ALDH2
Tclin
Family: Enzyme
Novelty: 0.00077122
p_int: 0.894939617
p_ni: 0.105060383
p_wrong: 1e-9
Score: 0.531
Data Source: BioPlex,STRINGDB
MPZL1
Tbio
Novelty: 0.03292508
p_int: 0.823829302
p_ni: 0.176170698
Score: 0.187
Data Source: BioPlex,STRINGDB
PRDX2
Tbio
Novelty: 0.00189751
p_int: 0.764722134
p_ni: 0.235277866
Score: 0.221
Data Source: BioPlex,STRINGDB
CYP26A1
Tchem
Family: Enzyme
Novelty: 0.00281805
Score: 0.991
Data Source: STRINGDB
CYP26B1
Tchem
Novelty: 0.00990332
Score: 0.978
Data Source: STRINGDB
CYP26C1
Tbio
Novelty: 0.04960237
Score: 0.964
Data Source: STRINGDB
RDH11
Tbio
Family: Enzyme
Novelty: 0.02758936
Score: 0.962
Data Source: STRINGDB
RDH12
Tbio
Family: Enzyme
Novelty: 0.016003
Score: 0.958
Data Source: STRINGDB
RDH5
Tbio
Family: Enzyme
Novelty: 0.0111079
Score: 0.954
Data Source: STRINGDB
DHRS3
Tbio
Family: Enzyme
Novelty: 0.04448013
Score: 0.951
Data Source: STRINGDB
Publication Statistics
PubMed Score  232.99

PubMed score by year
PubTator Score  79.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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