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Tbio
AQP8
Aquaporin-8

Protein Summary
Description
Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea. Aquaporin 8 (AQP8) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 8 mRNA is found in pancreas and colon but not other tissues. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219660
  • ENSP00000219660
  • ENSG00000103375

Symbol
  • AQP-8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.66
cell type or tissue
0.63
molecular function
0.6
tissue
0.59
protein domain
0.58


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.47   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.47   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aquaporin 8
VGNC:5674
468096
Macaque
aquaporin 8
702167
Mouse
MGI:1195271
11833
Rat
RGD:2146
29172
Dog
aquaporin 8
VGNC:38020
608036
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aquaporin 8
Macaque
aquaporin 8
Mouse
Rat
Dog
aquaporin 8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O94778-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Aquaporin-mediated transport (R-HSA-445717)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aquaporin-mediated transport
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Detoxification of Reactive Oxygen Species
Reactome
Passive transport by Aquaporins
Name
Explore in Pharos
Explore in Source
Aquaporin-mediated transport
Cellular responses to external stimuli
Cellular responses to stress
Detoxification of Reactive Oxygen Species
Passive transport by Aquaporins
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Protein-Protein Interactions (27)
1 – 10 of 27
AQP10
Tbio
Novelty:  0.03507619
Score:  0.933
Data Source:  STRINGDB
AQP12A
Tbio
Novelty:  0.04258853
Score:  0.903
Data Source:  STRINGDB
AQP11
Tbio
Novelty:  0.0229197
Score:  0.866
Data Source:  STRINGDB
LCMT1
Tbio
Family:  Enzyme
Novelty:  0.03504409
Score:  0.713
Data Source:  STRINGDB
RHBDF1
Tbio
Family:  Enzyme
Novelty:  0.01942693
Score:  0.708
Data Source:  STRINGDB
MGRN1
Tbio
Family:  Enzyme
Novelty:  0.04981605
Score:  0.641
Data Source:  STRINGDB
ARHGAP17
Tbio
Family:  Enzyme
Novelty:  0.06611987
Score:  0.64
Data Source:  STRINGDB
NPRL3
Tbio
Family:  Enzyme
Novelty:  0.0110744
Score:  0.636
Data Source:  STRINGDB
CAMK1
Tchem
Family:  Kinase
Novelty:  0.01239891
Score:  0.535
Data Source:  STRINGDB
MS4A12
Tdark
Novelty:  0.24047034
Score:  0.513
Data Source:  STRINGDB
Publication Statistics
PubMed Score  171.47

PubMed score by year
PubTator Score  77.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer