Tbio AQP8 Aquaporin-8

Protein Summary

Description

Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea. Aquaporin 8 (AQP8) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 8 mRNA is found in pancreas and colon but not other tissues. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O94778
• Q8IUU3
• Q9UIA4
• AQP-8

Gene Name

• AQP8

Ensembl ID

• ENST00000219660
• ENSP00000219660
• ENSG00000103375

Symbol

• AQP-8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.66
cell type or tissue	0.63
molecular function	0.6
tissue	0.59
protein domain	0.58

Protein Classes

DTO Classes

Protein / Ion Channel / Other Ion Channel / Aquaporin / Aquaporin-8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.43   (req: < 5)

Gene RIFs: 43   (req: <= 3)

Antibodies: 163   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.43   (req: >= 5)

Gene RIFs: 43   (req: > 3)

Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0