DPM2
Dolichol phosphate-mannose biosynthesis regulatory protein
Protein Summary
Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity. Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol ...more
- ENST00000314392
- ENSP00000322181
- ENSG00000136908
- CDG1U
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
kinase perturbation | 0.93 | ||
pathway | 0.83 | ||
transcription factor perturbation | 0.74 | ||
cellular component | 0.67 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.23 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 39 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.23 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 39 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | dolichyl-phosphate mannosyltransferase subunit 2, regulatory | VGNC:13873 | 100614286 | |||||
Macaque | dolichyl-phosphate mannosyltransferase subunit 2, regulatory | 698709 | ||||||
Mouse | MGI:1330238 | 13481 | ||||||
Rat | RGD:2514 | 29640 | ||||||
Dog | dolichyl-phosphate mannosyltransferase subunit 2, regulatory [Source:HGNC Symbol;Acc:HGNC:3006] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | dolichyl-phosphate mannosyltransferase subunit 2, regulatory | |||||
Macaque | dolichyl-phosphate mannosyltransferase subunit 2, regulatory | |||||
Mouse | ||||||
Rat | ||||||
Dog | dolichyl-phosphate mannosyltransferase subunit 2, regulatory [Source:HGNC Symbol;Acc:HGNC:3006] | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (22)
Reactome (14)
KEGG (3)
UniProt (1)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 14
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ||||
Reactome | Defective DPM1 causes DPM1-CDG (CDG-1e) | ||||
Reactome | Defective DPM2 causes DPM2-CDG (CDG-1u) | ||||
Reactome | Defective DPM3 causes DPM3-CDG (CDG-1o) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Asparagine N-linked glycosylation | ||||
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ||||
Defective DPM1 causes DPM1-CDG (CDG-1e) | ||||
Defective DPM2 causes DPM2-CDG (CDG-1u) | ||||
Defective DPM3 causes DPM3-CDG (CDG-1o) | ||||
Gene Ontology Terms (10)
Functions (1)
Components (4)
Processes (5)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (87)
1 – 10 of 87
DPM1
Family: Enzyme
Novelty: 0.01317862
Score: 0.997
Data Source: Reactome,STRINGDB
DPM3
Family: Enzyme
Novelty: 0.05248147
Score: 0.997
Data Source: Reactome,STRINGDB
PIGP
Family: Enzyme
Novelty: 0.01400934
Score: 0.989
Data Source: STRINGDB
PIGC
Family: Enzyme
Novelty: 0.02057578
Score: 0.989
Data Source: STRINGDB
PIGH
Family: Enzyme
Novelty: 0.0584561
Score: 0.985
Data Source: STRINGDB
PIGA
Family: Enzyme
Novelty: 0.00172769
Score: 0.983
Data Source: STRINGDB
DOLK
Family: Enzyme
Novelty: 0.00664639
Score: 0.982
Data Source: STRINGDB
DPAGT1
Family: Enzyme
Novelty: 0.00869839
Score: 0.978
Data Source: STRINGDB
PIGL
Family: Enzyme
Novelty: 0.03151013
Score: 0.976
Data Source: STRINGDB
PIGY
Family: Enzyme
Novelty: 0.17988252
Score: 0.974
Data Source: STRINGDB
Publication Statistics
PubMed Score 20.23
PubMed score by year
PubTator Score 8.29
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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