DPM2
Dolichol phosphate-mannose biosynthesis regulatory protein
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 1 | ||
kinase perturbation | 0.93 | ||
pathway | 0.83 | ||
transcription factor perturbation | 0.74 | ||
cellular component | 0.67 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ||||
Reactome | Defective DPM1 causes DPM1-CDG (CDG-1e) | ||||
Reactome | Defective DPM2 causes DPM2-CDG (CDG-1u) | ||||
Reactome | Defective DPM3 causes DPM3-CDG (CDG-1o) | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Asparagine N-linked glycosylation | ||||
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ||||
Defective DPM1 causes DPM1-CDG (CDG-1e) | ||||
Defective DPM2 causes DPM2-CDG (CDG-1u) | ||||
Defective DPM3 causes DPM3-CDG (CDG-1o) | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
hemoglobin measurement | 3 | 3 | 3 | 93.9 | |||||
hematocrit | 3 | 2 | 3 | 86.8 | |||||
monocyte count | 3 | 3 | 3 | 82.1 | |||||
urate measurement | 3 | 3 | 3 | 76.4 | |||||
red blood cell density measurement | 1 | 1 | 1 | 43.8 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
hemoglobin measurement | 3 | 93.9 | |||||
hematocrit | 3 | 86.8 | |||||
monocyte count | 3 | 82.1 | |||||
urate measurement | 3 | 76.4 | |||||
red blood cell density measurement | 1 | 43.8 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | dolichyl-phosphate mannosyltransferase subunit 2, regulatory | VGNC:13873 | 100614286 | |||||
Macaque | dolichyl-phosphate mannosyltransferase subunit 2, regulatory | 698709 | ||||||
Mouse | MGI:1330238 | 13481 | ||||||
Rat | RGD:2514 | 29640 | ||||||
Dog | dolichyl-phosphate mannosyltransferase subunit 2, regulatory [Source:HGNC Symbol;Acc:HGNC:3006] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | dolichyl-phosphate mannosyltransferase subunit 2, regulatory | |||||
Macaque | dolichyl-phosphate mannosyltransferase subunit 2, regulatory | |||||
Mouse | ||||||
Rat | ||||||
Dog | dolichyl-phosphate mannosyltransferase subunit 2, regulatory [Source:HGNC Symbol;Acc:HGNC:3006] | |||||
PMID | Year | Title |
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