DPM2
Dolichol phosphate-mannose biosynthesis regulatory protein
Protein Summary
Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity. Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol ...more
- ENST00000314392
- ENSP00000322181
- ENSG00000136908
- CDG1U
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
kinase perturbation | 0.93 | ||
pathway | 0.83 | ||
transcription factor perturbation | 0.74 | ||
cellular component | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.27 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 39 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.27 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 39 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (87)
Nearest Tclin Targets
Pathways (22)
Reactome (14)
KEGG (3)
UniProt (1)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ||||
Reactome | Defective DPM1 causes DPM1-CDG (CDG-1e) | ||||
Reactome | Defective DPM2 causes DPM2-CDG (CDG-1u) | ||||
Reactome | Defective DPM3 causes DPM3-CDG (CDG-1o) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Asparagine N-linked glycosylation | ||||
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ||||
Defective DPM1 causes DPM1-CDG (CDG-1e) | ||||
Defective DPM2 causes DPM2-CDG (CDG-1u) | ||||
Defective DPM3 causes DPM3-CDG (CDG-1o) | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (1)
Components (4)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
hemoglobin measurement | 3 | 3 | 3 | 93.9 | |||||
hematocrit | 3 | 2 | 3 | 86.8 | |||||
monocyte count | 3 | 3 | 3 | 82.1 | |||||
urate measurement | 3 | 3 | 3 | 76.4 | |||||
red blood cell density measurement | 1 | 1 | 1 | 43.8 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
hemoglobin measurement | 3 | 93.9 | |||||
hematocrit | 3 | 86.8 | |||||
monocyte count | 3 | 82.1 | |||||
urate measurement | 3 | 76.4 | |||||
red blood cell density measurement | 1 | 43.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | dolichyl-phosphate mannosyltransferase subunit 2, regulatory | VGNC:13873 | 100614286 | |||||
Macaque | dolichyl-phosphate mannosyltransferase subunit 2, regulatory | 698709 | ||||||
Mouse | MGI:1330238 | 13481 | ||||||
Rat | RGD:2514 | 29640 | ||||||
Dog | dolichyl-phosphate mannosyltransferase subunit 2, regulatory [Source:HGNC Symbol;Acc:HGNC:3006] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | dolichyl-phosphate mannosyltransferase subunit 2, regulatory | |||||
Macaque | dolichyl-phosphate mannosyltransferase subunit 2, regulatory | |||||
Mouse | ||||||
Rat | ||||||
Dog | dolichyl-phosphate mannosyltransferase subunit 2, regulatory [Source:HGNC Symbol;Acc:HGNC:3006] | |||||
Publication Statistics
PubMed Score 20.27
PubMed score by year
PubTator Score 8.29
PubTator score by year
Related Publications
Text Mined References (10)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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