Tchem STK17B Serine/threonine-protein kinase 17B

Protein Summary

Description

Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis.

Uniprot Accession IDs

• O94768

Gene Name

• STK17B

Ensembl ID

• ENST00000263955
• ENSP00000263955
• ENSG00000081320
• ENST00000409228
• ENSP00000386853

Symbol

• DRAK2
• DRAK2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.98
molecular function	0.9
transcription factor binding site profile	0.84
PubMedID	0.81
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Serine/threonine-protein Kinase 17b

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Dapk Family / Serine/threonine-protein Kinase 17b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.22   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 403   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.22   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 403   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 24

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1